Results 61 to 70 of about 283,427 (308)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Pendulum Has Swung: How Do We Ensure a Life Course Approach to Immunisation in Australia?

Frontiers in Public Health, 2022
Rather than concentrating primarily on children and adolescents, there has been a shift in the discourse around immunisation to encompass a whole-of-life approach.
Holly Seale, Kathleen McFadden, Amalie Dyda, Jessica Kaufman, Jessica Kaufman, Jessica Kaufman, Anita Heywood   +6 more
doaj   +1 more source

Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees [PDF]

, 2001
The radiation-attenuated Schistosoma mansoni vaccine is highly effective in rodents and primates but has never been tested in humans, primarily for safety reasons.
Abe K., Agnew A., Amory Soisson L., Aranda-Michel J., Araújo M. I., Ashton P. D., Bergquist N. R., Butterworth A. E., Butterworth A. E., Caldas I. R., Capron A., Carneiro-Santos P., Caulada-Benedetti Z., Chan M. S., Coulson P. S., de Clercq D., de Jonge N., Deelder A. M., Doetze A., Dunne D. W., Eberl M., Eberl M., Eberl M., Gryseels B, Gryseels B., Grzych J. M., Harrop R., Harrop R., Hsü S. Y., Jankovic D., Kardorff R., Kasper G., Katz N., Kuntz R. E., Mahmoud O. M., Malaquias L. C. C., Mansour M. M., Marguerite M., Medhat A., Montenegro S. M. L., Moser D., Olsen A., Omer F. M., Omer-Ali P., Pearce E. J., Pemberton R. M., Polman K., Prince A. M., Renquist D. M., Rieckmann K. H., Rocha M. O., Sadun E. H., Sadun E. H., Sher A., Smythies L. E., Sundstedt A., Tanner M., Velupillai P., Viana I. R., Viana I. R., von Lichtenberg F., von Lichtenberg F., Williams M. E., Wilson R. A., Yole D. S., Yole D. S.   +65 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Adult vaccination coverage in the United States: A database analysis and literature review of improvement strategies

Human Vaccines & Immunotherapeutics
Despite vaccines being instrumental in reducing vaccine-preventable disease, adult vaccination rates in the United States (US) are below optimal levels.
Amanda L. Eiden, Louise Hartley, Diana Garbinsky, Cassondra Saande, Jon Russo, Meghan Hufstader Gabriel, Mark Price, Alexandra Bhatti   +7 more
doaj   +1 more source

Varicella infections in patients with end stage renal disease: a systematic review

BMC Nephrology, 2018
Background End stage renal disease (ESRD) is on the rise globally. Varicella infection among adult patients with ESRD has been reported to lead to multiple complications and even death. While varicella vaccination has been recommended in paediatric renal
Chong Yau Ong, Sher Guan Low, Farhad Fakhrudin Vasanwala, Shashidhar Baikunje, Lian Leng Low   +4 more
doaj   +1 more source

The Effect of the COVID-19 Pandemic in Adult Vaccination in Turkey

Bagcilar Medical Bulletin, 2023
Objective:This study aimed to evaluate the impact of the Coronavirus disease-2019 (COVID-19) pandemic on adult vaccination rates in Turkey.Method:This retrospective descriptive study included individuals aged 18 and over who sought adult vaccination at ...
Feyzanur Erdem, Nilay Çom Aybal, Mahnur Mahdum, Seçil Arıca   +3 more
doaj   +1 more source

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques. [PDF]

, 2019
The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood.
Dinasarapu, Ashok R, Durbin-Johnson, Blythe P, Elizaldi, Sonny R, Iyer, Smita S, Kozlowski, Pamela A, Raeman, Reben, Rolston, Matthew, Settles, Matthew, Verma, Anil, Walter, Korey A   +9 more
core   +1 more source

The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout

Perspectives in Public Health, 2022
Aims: Development and rollout of vaccines offers the best opportunity for population protection against the SARS-CoV-2 (COVID-19) virus. However, hesitancy towards the vaccines might impede successful uptake in the United Kingdom, particularly in young adults who demonstrate the highest rates of hesitancy.
H Knight, R Jia, K Ayling, H Blake, JR Morling, AM Villalon, J Corner, C Denning, J Ball, K Bolton, G Figueredo, D Morris, P Tighe, K Vedhara   +13 more
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source