Results 141 to 150 of about 886,403 (306)
Brain damage following whooping cough vaccination : is it time to lay the myth to rest? [PDF]
, 1998 Whooping cough causes significant morbidity and mortality, especially in early infancy. Although an effective vaccine exists, vaccine uptake in Malta was previously disappointing due to the general public’s and the medical community’s doubts regarding ...
Busuttil, Ray, Grech, Victor E.
core
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Infectious Diseases and Therapy, 2020 Introduction An extensive clinical development program showed that the meningococcal serogroup B-factor H binding protein (MenB-FHbp) vaccine affords protection against MenB disease for adolescents and adults.
Johannes Beeslaar +7 more
doaj +1 more source
Inorganic Nanomaterials Meet the Immune System: An Intricate Balance
Advanced Healthcare Materials, EarlyView.Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli +3 more
wiley +1 more source
Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics
Advanced Healthcare Materials, EarlyView.This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold +2 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth +10 more
wiley +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics
Advanced Materials, EarlyView.Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE) is a novel 2PP resin family with sub‐micron resolution and tuneable hydrolysis. SCRIBE enables direct printing of hollow microparticles with complex chemistries and geometries inaccessible to molding techniques, which are used to modulate antibody titers and class switching as ...
David J. Peeler +16 more
wiley +1 more source
Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma
Advanced Materials, EarlyView.A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura +19 more
wiley +1 more source