Results 151 to 160 of about 1,325,849 (308)

Vaccination [PDF]

Science, 1894
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Vaccination [PDF]

BMJ, 1878
openaire   +2 more sources

All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery

Advanced Science, EarlyView.
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis, Soumen Saha, Xinghai Li, Max R. Ney, Sarah Y. Kim, Joshua J. Milligan, Lixin Fan, Matthew L. Becker, Daniel Reker, Ashutosh Chilkoti   +15 more
wiley   +1 more source

Uncovering mechanisms of HIV persistence in HIV controllers by HIV sequence analysis in CD4 T cell subsets

Journal of Virus Eradication, 2015
E. Boritz, S. Darko, F. Simonetti, D. Wells, X. Wu, L. Swaszek, G. Wolf, R. Hoh, A. Vostal, A. Ober, M. Hughes, D. Bunis, S. Migueles, J. Casazza, R. Koup, M. Connors, S. Moir, J. Martin, F. Maldarelli, S. Hughes, S. Deeks, D. Douek   +21 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Vaccines at the Heart of Hepatitis Elimination: Insights From the ESCMID Study Group for Viral Hepatitis (ESGVH). [PDF]

Liver Int
Săndulescu O, Şahin GÖ, Dudman SG, Said ZNA, Mondelli MU, ESCMID Study Group for Viral Hepatitis (ESGVH).   +5 more
europepmc   +1 more source

Vaccines [PDF]

Clinical Therapeutics, 2017
openaire   +2 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Social Media Perspectives on a Future HIV Vaccine: Mixed Methods Analysis. [PDF]

JMIR Infodemiology
Rabin MA, Penuela-Wermers S, Sehgal NKR, Egbe TI, Lavery CLM, Guntuku SC, Buttenheim AM.   +6 more
europepmc   +1 more source