Results 191 to 200 of about 2,206,632 (403)

Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study

, 2014
Glenda Gray, Zoe Moodie, Barbara Metch, Peter B. Gilbert, Linda‐Gail Bekker, Gavin Churchyard, Maphoshane Nchabeleng, Koleka Mlisana, Fatima Laher, Surita Roux, Kathryn Mngadi, Craig Innes, Matsontso Mathebula, Mary Allen, Margaret J McElrath, Michael Robertson, James G. Kublin, Lawrence Corey   +17 more
openalex   +2 more sources

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Use of verbal autopsy to determine mortality patterns in an urban slum in Kolkata, India

Bulletin of the World Health Organization, 2010
OBJECTIVE: To define mortality patterns in an urban slum in Kolkata, India, in the context of a cholera and typhoid fever project. METHODS: In a well-defined population that was under surveillance for 18 months, we followed a dynamic cohort of 63788 ...
Suman Kanungo, Ataru Tsuzuki, Jacqueline L Deen, Anna Lena Lopez, Krisnan Rajendran, Byomkesh Manna, Dipika Sur, Deok Ryun Kim, Vinay Kumar Gupta, R Leon Ochiai, Mohammad Ali, Lorenz von Seidlein, Sujit K Bhattacharya, John D Clemens   +13 more
doaj  

Assessment of Two Novel Live-Attenuated Vaccine Candidates for Herpes Simplex Virus 2 (HSV-2) in Guinea Pigs [PDF]

, 2021
Jonathan D. Joyce, Anant K. Patel, Brandie Murphy, Daniel J.J. Carr, Edward Gershburg, Andrea S. Bertke   +5 more
openalex   +1 more source

The COVID-19 vaccine development landscape

Nature reviews. Drug discovery, 2020
Tung Thanh Le, Zacharias E. Andreadakis, Arun Kumar, Raúl Gómez Román, S. Tollefsen, M. Saville, Stephen Mayhew   +6 more
semanticscholar   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Synthetic Malaria Peptide Vaccine Elicits High Levels of Antibodies in Vaccinees of Defined HLA Genotypes [PDF]

, 2000
Elizabeth Nardin, Giane A. Oliveira, J. Mauricio Calvo‐Calle, Z Castro, R S Nussenzweig, Barbara J. Schmeckpeper, Bradford Hall, Carter L. Diggs, Sacared A Bodison, Robert Edelman   +9 more
openalex   +1 more source

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Nature, 2020
U. Şahin, A. Muik, E. Derhovanessian, I. Vogler, L. Kranz, M. Vormehr, A. Baum, Kristen E. Pascal, Jasmin Quandt, D. Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, R. Hilker, D. Becker, Ann-Kathrin Eller, J. Grützner, Carsten Boesler, Corinna Rosenbaum, Marie-Cristine Kühnle, U. Luxemburger, Alexandra Kemmer-Brück, D. Langer, M. Bexon, S. Bolte, K. Karikó, T. Palanché, Boris Fischer, A. Schultz, P. Shi, Camila R. Fontes-Garfias, John L. Perez, K. Swanson, Jakob Loschko, Ingrid L Scully, Mark Cutler, W. Kalina, C. Kyratsous, David Cooper, P. Dormitzer, K. Jansen, Ö. Türeci   +41 more
semanticscholar   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source