Results 221 to 230 of about 857,892 (246)

Precision Targeting of Myeloid Cells via Peptide Dendrimer‐Lipid Nanocarriers: A Novel Platform for Potent Cancer Immunotherapies

Advanced Science, EarlyView.
Precision targeting of the spleen and myeloid cells of the tumor microenvironment, with minimal hepatic delivery, is achieved using a modular peptide dendrimer‐lipid nanocarrier. Functional assays, transcriptomics, and rodent models validate this novel myeloid cell targeting nanocarrier as an efficacious immunotherapy, both as a cancer vaccine platform
Lawrence James Billing, Liam Martin, Tristan Henser‐Brownhill, Parisa Samangouei, Adam Leach, Phoebe Knight, Marina Apostolidou, Aaqib Ladak, Benita Nagel, Albert Kwok   +9 more
wiley   +1 more source

Ethical aspects of vaccines and vaccination

Vaccine, 1998
openaire   +3 more sources

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source

Rapid and Ultra‐Sensitive SARS‐CoV‐2 Subgenomic RNA Detection Using Single‐Molecule With a Large Transistor‐SiMoT Bioelectronic Platform

Advanced Electronic Materials, EarlyView.
The single‐molecule with a large transistor‐SiMoT is proposed for the detection of the subgenomic RNA of SARS‐CoV‐2, achieving a diagnostic sensitivity of 98.0% and a specificity of 87.8%. The SiMoT technology, currently at TRL‐5, is suitable for point‐of‐care settings and delivers the result to the end user in 30 min.
Eleonora Macchia, Anna Maria D'Erchia, Mariapia Caputo, Angelica Bianco, Claudia Leoni, Francesca Intranuovo, Cecilia Scandurra, Lucia Sarcina, Cinzia Di Franco, Paolo Bollella, Gaetano Scamarcio, Luisa Torsi, Graziano Pesole   +12 more
wiley   +1 more source

Manual Activation of Metal‐Like Patterns in Leather for Stable Electrical Signal Transmission

Advanced Electronic Materials, EarlyView.
This work proposes a strategy in which EGaIn particles are fused within the leather matrix through a handwritten sintering process, resulting in the fabrication of highly conductive metal‐like leather (MLL). MLL not only retains the comfort and breathability of leather but also allows for reliable electrical signal transmission.
Weikang Chen, Weiyao Wu, Yifei Sun, Shuping Jia, Lingling Huang, Fengwei Huo, Ruijie Xie   +6 more
wiley   +1 more source

Engineered Nile Red Derivatives‐Mediated Efficient Phototherapy Against Drug‐Resistant Bacteria and Monkeypox Virus

Aggregate, EarlyView.
TPAOMCN exhibits optimal reactive oxygen species (ROS) generation and photothermal conversion properties. TPAOMCN nanofibers (NFs)‐mediated photodynamic (PDT) and photothermal therapy (PTT) achieved efficient eradication against multidrug‐resistant bacteria and viruses, alleviating inflammation response, promoting wound healing, and providing a ...
Laiping Fang, Wei Wang, Jianan Dai, Yike Tu, Shufang Li, Kuo He, Siya Tong, Yuhui Liao, Ping'an Ma, Guihua Jiang   +9 more
wiley   +1 more source

Illuminating the Unseen and Targeting the Untreatable: Aggregation‐Induced Emission Nanoparticles as Intelligent, Immune‐Compatible Tools for Precision Cancer Theranostics

Aggregate, EarlyView.
Rationally engineered AIE nanoparticles can unite deep‐tissue imaging, photodynamic therapy, photothermal therapy, and immune microenvironment reprogramming. Through precise photophysical tuning and targeted delivery, these intelligent nanoplatforms enable real‐time monitoring, potent tumor eradication, and immune activation, offering a versatile and ...
Quazi T. H. Shubhra, Robert Musiol, Huachun Pan, Qiang Cai, Xiaosong He, Xiaojun Cai   +5 more
wiley   +1 more source

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Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults.

New England Journal of Medicine, 2023
BACKGROUND Respiratory syncytial virus (RSV) infection causes considerable illness in older adults. The efficacy and safety of an investigational bivalent RSV prefusion F protein-based (RSVpreF) vaccine in this population are unknown.
E. Walsh, Gonzalo Pérez Marc, A. Zareba, A. Falsey, Q. Jiang, Michael Patton, F. Polack, C. Llapur, P. A. Doreski, Kumar Ilangovan, M. Rämet, Yasushi Fukushima, Nazreen Hussen, L. Bont, Jose Cardona, E. Dehaan, Giselle Castillo Villa, M. Ingilizova, D. Eiras, T. Mikati, Rupal N Shah, Kathy Schneider, David Cooper, K. Koury, M. Lino, A. Anderson, K. Jansen, K. Swanson, A. Gurtman, W. Gruber, B. Schmoele-Thoma   +30 more
semanticscholar   +1 more source

Vaccines, vaccination in Brucellosis

Annales de l'Institut Pasteur / Microbiologie, 1987
International ...
Plommet, Michel, Serre, A., Fensterbank, R.   +2 more
openaire   +4 more sources