Results 261 to 270 of about 2,182,415 (399)

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

Vaccines to prevent bacterial sexually transmitted infections: Promise, progress, and public health potential. [PDF]

PLoS Med
Gottlieb SL, Rees H, Peters RPH.
europepmc   +1 more source

Lipopolyplex-formulated mRNA cancer vaccine elicits strong neoantigen-specific T cell responses and antitumor activity [PDF]

Ting Fan, Congcong Xu, Jichuan Wu, Yihua Cai, Wanlu Cao, Haifa Shen, Mingna Zhang, Hanfei Zhu, Jingxian Yang, Zhounan Zhu, Xiaopin Ma, Jiale Ren, Lei Huang, Qianyun Li, Yuying Tang, Bo Yu, Chunxiu Chen, Mingcheng Xu, Qiuhe Wang, Zhuya Xu, Fengjia Chen, Shujing Liang, Zhixian Zhong, Anmbreen Jamroze, Dean G. Tang, Hangwen Li, Chunyan Dong   +26 more
openalex   +1 more source

Adjuvanted influenza vaccines [PDF]

, 2012
Nicola Principi, Susanna Esposito
openalex   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

Knowledge, Attitude, and Intention to Receive the Pertussis Vaccine in Pregnant Women: A Systematic Review. [PDF]

Healthcare (Basel)
Ługowski F, Babińska J, Urban A, Kacperczyk-Bartnik J, Bartnik P, Romejko-Wolniewicz E, Sieńko J.   +6 more
europepmc   +1 more source

Vaccines and vaccination

, 2010
John D. Grabenstein, Walter L. Straus, Mark B. Feinberg   +2 more
openaire   +1 more source

Vaccination [PDF]

BMJ, 1878
openaire   +2 more sources

Ionizable lipid nanoparticles of mRNA vaccines elicit NF-κB and IRF responses through toll-like receptor 4 [PDF]

Amanda E Zelkoski, Zhongyan Lu, Gauthaman Sukumar, Clifton L. Dalgard, Hooda Said, Mohamad‐Gabriel Alameh, Edward Mitre, Allison M. W. Malloy   +7 more
openalex   +1 more source