Results 341 to 350 of about 2,114,452 (380)

Developing a Personalized Cancer Nanovaccine Using Coxsackievirus‐Reprogrammed Cancer Cell Membranes for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
A personalized nanovaccine combining PLGA‐encapsulated heat‐inactivated CVB3 and membranes from CVB3‐infected breast cancer cells stimulates potent antitumor immunity. It reduces immunosuppressive markers, enhances immune activation, and improves survival in vivo.
Amirhossein Bahreyni, Yasir Mohamud, Amrit Singh, Razieh Sadat Banijamali, Jeffrey Tang, Jingchun Zhang, Honglin Luo   +6 more
wiley   +1 more source

PLAUR+ Neutrophils Drive Anti‐PD‐1 Therapy Resistance in Patients with Hepatocellular Carcinoma by Shaping an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
The present study reveals that PLAUR+ neutrophils are enriched in immunotherapy non‐responders and correlate with poor prognosis. PLAUR+ neutrophils dictate immunotherapy resistance in hepatocellular carcinoma by forming an immunosuppressive tumor microenvironment characterized by CD8+ T cell exclusion and macrophage‐dependent immune suppression.
Shaoqing Liu, Yanzhao Zhou, Gaoxiang Li, Bingwen Zhu, Fang Wu, Jinxue Zhou, Xiaobing Chen, Bo Qin, Yanxia Gao, Fazhan Wang, Yong Jiang, Wenxin Xu   +11 more
wiley   +1 more source

Design of a multi-epitope vaccine against drug-resistant mycobacterium tuberculosis and mycobacterium bovis using reverse vaccinology. [PDF]

Sci Rep
Akurut E, Gavamukulya Y, Mulindwa J, Isiagi M, Galiwango R, Bbuye M, Lujumba I, Kiberu D, Nabisubi P, Kebirungi G, Kambugu A, Castelnuovo B, Nkurunungi G, Jjingo D, Oketch B, Kateete DP, Mboowa G.   +16 more
europepmc   +1 more source

Recent Developments in Nanoparticle‐Hydrogel Hybrid Materials for Controlled Release

Advanced Science, EarlyView.
This review highlights recent advances in nanoparticle–hydrogel hybrid materials for controlled drug delivery. It explores diverse nanocarrier–hydrogel combinations, drug loading strategies, release mechanisms, and stimuli‐responsive behaviors. Emphasis is placed on the molecular interactions driving hybrid material performance, offering insights into ...
Yiping Fan, Qi Han, Haiyan Li, Xudong Cai, Brendan Dyett, Ruirui Qiao, Calum J. Drummond, San H. Thang, Jiali Zhai   +8 more
wiley   +1 more source

Community engagement in promoting malaria vaccine uptake for children Under-Five. [PDF]

Sci Rep
Adoma PO, Acquah F, Yakubu A, Cudjoe L, Achiam WKK, Agorinya IA.   +5 more
europepmc   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Immunoinformatic design of chimeric multiepitope vaccine for the prevention of human metapneumovirus (hMPV). [PDF]

BMC Infect Dis
Ehsasatvatan M, Kohnehrouz BB, Salavatizadeh M.   +2 more
europepmc   +1 more source

Decoy Extracellular Vesicles Overcome Triple‐Negative Breast Cancer Heterogeneity via Membrane‐Cytoplasm‐Mitochondria Cascade Targeting

Advanced Science, EarlyView.
siT/MOF@EVs overcome TNBC heterogeneity through a tumor cell membrane–cytoplasm–mitochondria cascade effect, triggering a self‐reinforcing anti‐tumor immune cycle and durable immune memory. The system enables sequential targeting of membrane checkpoints ligands (decoy effect), cytoplasmic siRNA delivery (CSC suppression), and mitochondrial MOF ...
Chuanrong Chen, Ming Shen, Xiaofeng Wan, Lili Sheng, Na Hao, Man Li, Menglin Xu, Yang He, Jiali Zhang   +8 more
wiley   +1 more source