Results 121 to 130 of about 1,007,353 (300)

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

COVID-19 vaccine acceptance and hesitancy rates by country.

, 2022
COVID-19 vaccine acceptance and hesitancy rates by country.
Pradeep Paul George (10025096), Penny Lun (9619621), Chou Chuen Yu (13899661), Jonathan Gao (3539495), Khalid Abdul Jabbar (10494544), Bernard Tang (13899658), James Alvin Low (10092851)   +6 more
core   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

The trend of vaccine acceptance, hesitance and refusal.

, 2023
The trend of vaccine acceptance, hesitance and refusal.
Chanikarn Netrpukdee (14755676), Orana Chandrasiri (14755682), Viroj Tangcharoensathien (632379), Hathairat Kosiyaporn (7180853), Nattanicha Pangkariya (14755679)   +4 more
core   +1 more source

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source

Parental acceptance of Human Papillomavirus vaccines

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2008
To determine whether parents would accept Human Papillomavirus (HPV) vaccination for their children and which variables may influence their decision, including knowledge about cervical cancer and HPV.Three hundred and fifty-six parents of children aged 10-12 years were interviewed regarding the acceptance of an HPV vaccine for their children and their ...
Lenselink, C.H., Gerrits, M.M., Melchers, W.J.G., Massuger, L.F.A.G., Hamont, D. van, Bekkers, R.L.M.   +5 more
openaire   +3 more sources

Physicians’ Approach to Vaccination Against COVID-19 Infection and Factors Affecting Vaccine Acceptance

Objective: Healthcare professionals play a pivotal role in shaping society’s attitudes towards vaccines. The aim of this study is to assess vaccine hesitancy and acceptance among physicians toward COVID-19 vaccines and to identify the factors influencing
Tuğçe Eşkazan, Selçuk Candan, Oğuz Kağan Bakkaloğlu, Süleyman Yıldırım, İbrahim Hatemi   +4 more
core   +1 more source

COVID-19 vaccine acceptance and hesitancy among the respondents.

, 2022
COVID-19 vaccine acceptance and hesitancy among the respondents.
Ashish Joshi (6541886), Ashruti Bhatt (12850595), Ayman El-Mohandes (3874468), Denis Nash (164689), Krishna Mohan Surapaneni (9269383), Mahima Kaur (11271090)   +5 more
core   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine

, 2012
Adults 40 years of age and older have been shown to be hypo-responsive immunologically to the currently available hepatitis B virus (HBV) vaccines. Three intramuscular doses of a Toll-like receptor 9 agonist, 1018 immunostimulatory sequence (1018 ISS ...
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