Results 191 to 200 of about 1,007,353 (300)

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

COVID-19 vaccine acceptance and uptake in Indonesia, Nepal, and Vietnam: Key lessons from a qualitative study. [PDF]

PLOS Glob Public Health
Sutrisni IA, Pham-Tram V, Duwal M, Nguyen Thanh H, Timoria D, Kekalih A, Friska D, Dien R, Bogh C, Nguyen Thanh P, Hamers RL, Karkey A, Lewycka S, Chambers M, Van Nuil JI.   +14 more
europepmc   +1 more source

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola, Aleksandar Gigov, Hubertus G. M. Leufkens, Andrew Bate, Marie Louise De Bruin, Helga Gardarsdottir   +5 more
wiley   +1 more source

Effectiveness of a video-based intervention for COVID-19 vaccine acceptance among individuals with mental disorders: a randomized online experiment. [PDF]

Front Public Health
Huth D, Hennemann S, Witthöft M, Bräscher AK.   +3 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Navigating through HPV stigma: an intersectional lens on community engagement for vaccine acceptance in Pakistan. [PDF]

Lancet Reg Health Southeast Asia
Ali I, Sharif A, Qamar A, Sadique S, Elbarazi I.   +4 more
europepmc   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

COVID-19 vaccine acceptance among non-communicable disease patients in Haiti. [PDF]

Front Public Health
Toussaint E, Dawson C, Fénelon DL, Morris SM, Enoise F, Lolagne R, Chery MJ, Dubique K, Clisbee M, Laneau D, Kwan GF.   +10 more
europepmc   +1 more source

Awareness of the Black Triangle Scheme among healthcare professionals and consumers in Australia: A mixed‐methods study exploring reporting intentions and suggested improvements

British Journal of Clinical Pharmacology, EarlyView.
Aims The Black Triangle Scheme, introduced in 2018 in Australia, does not appear to have increased the quantity of adverse drug event (ADE) reports. This study evaluated healthcare professionals' (HCPs') and consumers' awareness of the scheme, its influence on intentions for future ADE reporting, and suggested improvements.
Eyob Alemayehu Gebreyohannes, Sieta T. de Vries, Mohammed Gebre Dedefo, Oliver Frank, Myra Thiessen, Lisa Kalisch Ellett, Christopher Thornton, Renly Lim   +7 more
wiley   +1 more source

Message framing, identity congruence, and polio vaccine acceptance in Pakistan: Testing a social identity-based communication framework. [PDF]

J Virus Erad
Aslam S, Abid S, Ali A, Bilal MZ, Hussain B.   +4 more
europepmc   +1 more source