Results 131 to 140 of about 330,204 (355)

A Cryoprotectant‐Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals

Advanced Materials, EarlyView.
A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee, Seongchan Kim, Jooyeun Chong, Min‐gyeong Kim, Kayeong Lim, Nan‐Ee Lee, Jahyun Koo, Jiheong Kang, Hyojin Lee   +8 more
wiley   +1 more source

Waning effectiveness of mRNA COVID-19 vaccines against inpatient and emergency department encounters.

PLoS ONE
In the United States, most real-world estimates of COVID-19 vaccine effectiveness are based on data drawn from large health systems or sentinel populations.
Theodoros V Giannouchos, Nicole L Hair, Bankole Olatosi, Xiaoming Li   +3 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Heterogeneity in influenza seasonality and vaccine effectiveness in Australia, Chile, New Zealand and South Africa: early estimates of the 2019 influenza season [PDF]

, 2019
Sheena G. Sullivan, Carmen Sofia Arriola, Judy Bocacao, Pamela Burgos, Patricia Bustos, Kylie Carville, Allen Cheng, Monique BM Chilver, Cheryl Cohen, Yi‐Mo Deng, Nathalie El Omeiri, Rodrigo Fasce, Orienka Hellferscee, Q. Sue Huang, M. Cecilia Gonzalez Corcia, Lauren Jelley, Vivian Leung, Liza Lopez, Johanna M. McAnerney, Andrea McNeill, María Fernanda Olivares, Heidi Peck, Viviana Sotomayor, Stefano Tempia, Natalia Vergara, Anne von Gottberg, Sibongile Walaza, Timothy Wood   +27 more
openalex   +1 more source

Relative Effectiveness of Cell-Cultured versus Egg-Based Seasonal Influenza Vaccines in Preventing Influenza-Related Outcomes in Subjects 18 Years Old or Older: A Systematic Review and Meta-Analysis

, 2021
Joan Puig‐Barberà, Sonia Tamames, Pedro Plans-Rubió, José María Eirós-Bouza   +3 more
openalex   +2 more sources

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Incremental effectiveness of the second dose of mumps-containing vaccine among children 9 months to 6 years in Hefei: A matched case-control study

Human Vaccines & Immunotherapeutics
To evaluate the incremental vaccine effectiveness (IVE) of the second dose of mumps-containing vaccine (2thMuCV) compared to first dose and to provide evidence for optimizing mumps immunization strategies. We conducted a 1:1 matched case-control study of
Tingting Shi, Die Hu, Shuangshuang Deng, Guangbo Qu, Baozhen Peng, Yun Zhang, Yuhui Jin   +6 more
doaj   +1 more source

Cost-effectiveness analysis of 13-valent pneumococcal conjugate vaccine versus 23-valent pneumococcal polysaccharide vaccine in an adult population in South Korea [PDF]

, 2018
Min-Joo Choi, Shin-On Kang, Jin-Jeong Oh, Seong‐Beom Park, Min Ja Kim, Hee Jin Cheong   +5 more
openalex   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Human Papillomavirus: How Social Ideologies Influence Medical Policy and Care [PDF]

, 2012
The purpose of this paper is to discuss the ways in which new advances in the production of a vaccine against human papillomavirus (HPV) have been received by both the general public and the medical community.
Hachem, Fadi
core   +1 more source