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Vaccine, 2016
The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important ...
Mitra Saadatian-Elahi +8 more
openaire +3 more sources
The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important ...
Mitra Saadatian-Elahi +8 more
openaire +3 more sources
American Journal of Epidemiology, 1995
It is unlikely that human immunodeficiency virus (HIV) vaccines will create impenetrable barriers to infection. When the barriers to infection are broken, however, vaccine effects on the progression of infection to disease and on the contagiousness of infection could be considerable. The usual outcomes of vaccine trials are either infection or disease.
J S, Koopman, R J, Little
openaire +2 more sources
It is unlikely that human immunodeficiency virus (HIV) vaccines will create impenetrable barriers to infection. When the barriers to infection are broken, however, vaccine effects on the progression of infection to disease and on the contagiousness of infection could be considerable. The usual outcomes of vaccine trials are either infection or disease.
J S, Koopman, R J, Little
openaire +2 more sources
Nonspecific Effects of Vaccines
JAMA, 2014Vaccination is one of the great public health achievements of the last 100 years.1 The development of vaccination has led to the eradication of smallpox, the reduction of the worldwide incidence of polio by 99%, and the control of measles, with a 74% decline in global measles deaths since 2000.2 With the decline in vaccine-preventable diseases that ...
David, Goldblatt, Elizabeth, Miller
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Evaluating Typhoid Vaccine Effectiveness in Travelers' Vaccination
Journal of Travel Medicine, 2015Typhoid fever exists somewhere in the borderlines of the neglected tropical diseases. Its history in Europe and North America, and market for vaccination of travelers, means that typhoid is not entirely in the pharmaceutical public health wilderness. Travel immunization recommendations, however, are based on the results of efficacy trials performed in ...
openaire +2 more sources