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Live Attenuated Vaccine Vectors

International Journal of Technology Assessment in Health Care, 1994
AbstractSeveral different live attenuated vaccine vectors currently are under development. These vaccines are composed of living viruses or bacteria that are innocuous to the host but can replicate in host tissues and induce immune responses. The genes encoding foreign antigens can be inserted into these vectors to produce multivalent vaccines that ...
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Live attenuated influenza vaccine

2008
The development of the live, attenuated influenza vaccine (LAIV), based on the cold-adapted (ca), attenuated ca A/Ann Arbor/6/60 and ca B/Ann Arbor/1/66 backbones, has spanned several decades. The vaccine contains three vaccine strains, two attenuated influenza A strains and one attenuated influenza B strain; these vaccine strains are genetic ...
Harry B. Greenberg   +2 more
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Bacterial attenuation and vaccines

2023
58 pages, 1 table, 1 ...
Villa, Tomás G.   +6 more
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Live Attenuated Influenza Vaccine - A review

Journal of preventive medicine and hygiene, 2011
Owing to the variability of influenza viruses, vaccine composition needs to be up-dated annually. As many variables can influence their efficacy, vaccines are still considered ?sub-optimal?. Many studies have been carried out in recent years to improve vaccines.
GASPARINI, ROBERTO   +3 more
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Vaccination of Adults With Live Attenuated Mumps Virus Vaccine

JAMA: The Journal of the American Medical Association, 1967
A controlled study with live attenuated mumps virus vaccine, B level Jeryl Lynn strain, was conducted on adults without a history of mumps. Altogether, 95 men and women were vaccinated and sera were obtained prior to and 28 days following vaccination for the purpose of measuring initial serologic status for mumps and for ascertaining antibody responses.
Davidson Wl   +4 more
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Vaccination with Live Attenuated Measles Virus

Archives of Pediatrics & Adolescent Medicine, 1962
Introduction Isolation of the virus of measles in human tissue culture and its subsequent adaptation to growth in embryonated eggs and chick embryo cell culture by Enders and his colleagues 1-3 has led to the rapid development in the United States of vaccines suitable for use in the immunoprophylaxis of this disease.
Richard B. Hornick   +2 more
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Stability of Further-Attenuated Measles Vaccines

Clinical Infectious Diseases, 1983
Accelerated stability tests on lyophilized measles vaccines show two distinct mechanisms of virus inactivation. A rapid initial loss of infectivity occurs only on exposure to temperatures above the ambient temperature. This loss is temperature related and may be attributable to the movement of residual moisture from the virus pellet into the void space
P. Tam   +5 more
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A Trial With Live Attenuated Rubella Vaccine

Archives of Pediatrics & Adolescent Medicine, 1968
CONTROLLED trials of a high passage rubella virus strain conducted by Meyer et al in institutionalized human subjects 1 indicated that the virus was attenuated, immunogenic, and did not spread from vaccinees to others. The present investigation was undertaken to extend these observations in younger institutionalized subjects.
D. D. Hostetler   +3 more
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Live Attenuated Viral Vaccines

2014
The history of vaccination using live viruses extends through several centuries and is directly intertwined with the elimination of smallpox (variola major, Plotkin and Plotkin 2004). The word vaccine comes from the Latin “vaccinus” meaning “of cows”—an adjective joining variola (smallpox) and vaccinae to form cowpox (variola vaccinae, Jenner 1798 ...
Kuldip Sra   +3 more
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Live Attenuated Oral Poliovirus Vaccine

Clinical Infectious Diseases, 1984
During 1952-1954, some of the first papers were published on the attenuation of wild poliovirus for vaccine purposes. These efforts soon came to fruition , and large-scale field trials were held in many countries under a variety of conditions. Routine use of live oral poliovirus vaccines ( OPV ) was begun in many countries during the spring of 1960 ...
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