Results 281 to 290 of about 1,591,431 (356)

Editorial: Advancing livestock health: innovative vaccine strategies to combat antimicrobial resistance. [PDF]

Front Immunol
Uddin MB, Hewawaduge C.
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, EarlyView.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +2 more sources

Harnessing conserved epitopes and multivalent antigen strategies for vaccine design: Lessons learned and opportunities. [PDF]

Hum Vaccin Immunother
Adjei-Gati E, Quaye CNO, Lamptey PO, Oklu LD, Kwofie JN, Hafiz YA, Kusi KA.   +6 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

A Comparative Review of Veterinary and Human Vaccine Development Strategies: Insights into Herpesvirus Vaccinology from Latency to Elimination. [PDF]

Vaccines (Basel)
Liu G, Zhao X, Lin Y, Wang X, Liu D.
europepmc   +1 more source

mRNA vaccines in oncology: personalized cancer immunization and neoantigen targeting. [PDF]

Mol Cell Oncol
Parganiha M, Rathored J, Sai Painkra D.
europepmc   +1 more source

The case for an Epstein-Barr virus vaccine: Lessons from its link to systemic lupus erythematosus. [PDF]

Hum Vaccin Immunother
Akingbola A, Idahor C, Adegbesan A, Fakiyesi T, Aikulola O, Tundealao S, Mariaria P.   +6 more
europepmc   +1 more source

Tracking Canada's 2015 vaccine research and development priorities: Where are we a decade later? [PDF]

Can Commun Dis Rep
Moqueet N, Lago K, Cortés-Kaplan S, Birdi H, Desai S, Gauhar A, Warshawsky B, Tunis M, Wilkinson K.   +8 more
europepmc   +1 more source