Immunization with HIV-1 envelope T20-encoding DNA vaccines elicits cross-clade neutralizing antibody responses. [PDF]
Hum Vaccin Immunother, 2017 Background: Genetic immunization is expected to induce the expression of antigens in a native form. The encoded peptide epitopes are presented on endogenous MHC molecules, mimicking antigen presentation during a viral infection.
Stenler S +12 more
europepmc +4 more sources
Developing a Vaccine Against Human Cytomegalovirus: Identifying and Targeting HCMV's Immunological Achilles' Heel. [PDF]
Vaccines (Basel)Human cytomegalovirus (HCMV) is a critical pathogen in immunocompromised populations, such as organ transplant recipients as well as congenitally infected neonates with immature immune systems. Despite decades of research and the growing financial burden
Lankina A +5 more
europepmc +3 more sources
Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia. [PDF]
Clin Vaccine Immunol, 2016 ABSTARCT: Multifunctional T cells have been shown to be protective in chronic viral infections. In mycobacterial infections, however, evidence for a protective role of multifunctional T cells remains inconclusive.
Arroyo L +4 more
europepmc +3 more sources
Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice. [PDF]
J Immunol Res, 2017 Reverse transcriptase (RT) is a key enzyme in viral replication and susceptibility to ART and a crucial target of immunotherapy against drug‐resistant HIV‐1. RT induces oxidative stress which undermines the attempts to make it immunogenic. We hypothesized that artificial secretion may reduce the stress and make RT more immunogenic.
Latanova A +11 more
europepmc +2 more sources
Hyperloop Academic Research: A Systematic Review and a Taxonomy of Issues
Applied Sciences, 2021 Hyperloop is a proposed very high-speed ground transportation system for both passenger and freight that has the potential to be revolutionary, and which has attracted much attention in the last few years.
Konstantinos Gkoumas
doaj +1 more source
Energies, 2021 This paper presents the concept of one possible but unconventional implementation of a Low Pressure Tube Transport (LPTT) system for a network with station-to-station distances of 300 km, based on the use of circular tunnels in which modular vehicles ...
Janusz Piechna
doaj +1 more source
Who funded the research behind the Oxford-AstraZeneca COVID-19 vaccine? [PDF]
, 2021 Objectives The Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19, Vaxzevira or Covishield) builds on two decades of research and development (R&D) into chimpanzee adenovirus-vectored vaccine (ChAdOx) technology at the University of Oxford.
Banerjee, Rishi +9 more
core +1 more source
Prospects of Hyperloop Transportation Technology: A Case of China [PDF]
, 2019 Hyperloop transportation technology is amongst the most promising sustainable and climate-friendly transportation systems of the modern era. Now China has taken steps to build this transportation system in Tongren city, which located on Guizhou's eastern
A S M Sharifuzzaman Sagar +2 more
core +3 more sources
How Can Autonomous and Connected Vehicles, Electromobility, BRT, Hyperloop, Shared Use Mobility and Mobility-As-A-Service Shape Transport Futures for the Context of Smart Cities? [PDF]
, 2017 A smarter transport system that caters for social, economic and environmental sustainability is arguably one of the most critical prerequisites for creating pathways to more livable urban futures.
Carr +10 more
core +2 more sources
Analytical Model of Fluid Flow through Closed Structures for Vacuum Tube Systems
Mathematical Problems in Engineering, Volume 2015, Issue 1, 2015., 2015 An analytical model is developed to evaluate airtightness, which is one of the most important requirements of vacuum tube transportation systems. The main objective of the model is to anticipate the pressure inside a closed structure, which initially decreases and then rises with time owing to the inflow of the air outside.
Chan-Hee Park +3 more
wiley +1 more source