Results 61 to 70 of about 288,332 (292)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Development of a General Modelling Methodology for Vacuum Residue Hydroconversion

Oil & Gas Science and Technology, 2013
This work concerns the development of a methodology for kinetic modelling of refining processes, and more specifically for vacuum residue conversion.
Pereira de Oliveira L., Verstraete J. J., KoIb M.   +2 more
doaj   +1 more source

Nucleon QCD sum rules in nuclear matter including radiative corrections

, 2009
We calculate the nucleon parameters in nuclear matter using the QCD sum rules method. The radiative corrections to the leading operator product expansion terms are included, with the corrections of the order \alpha_s beyond the logarithmic approximation ...
E. G. Drukarev, E. G. Drukarev, E. G. Drukarev, F. J. Yndurain, M. G. Ryskin, V. A. Sadovnikova   +5 more
core   +1 more source

Higgs Mechanism in Nonlocal Field Theories [PDF]

, 2018
We study spontaneous gauge symmetry breaking and the Higgs mechanism in nonlocal field theories. Motivated by the level truncated action of string field theory, we consider a class of nonlocal field theories with an exponential factor of the d ...
Hashi, Manami Noumi, Isono, Hiroshi, Noumi, Toshifumi, Shiu, Gary, Soler, Pablo   +4 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Calculation of the Rate Constants of Vacuum Residue Hydrogenation Reactions in the Presence of a Chrysotile/NiTi Nanocatalyst

Fuels
The paper presents the results of an investigation into the kinetics of catalytic hydrogenation of vacuum residue at temperatures of 380, 400 and 420 °C and different durations, ranging from 30 to 70 min, using a nanocatalyst containing the active metals
Nazerke Balpanova, Murzabek Baikenov, Assanali Ainabayev, Aikorkem Kyzkenova, Gulzhan Baikenova, Almas Tusipkhan   +5 more
doaj   +1 more source

Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids [PDF]

, 1974
The characteristics of organosilicon compounds for lubrication under extreme conditions are discussed. The substances considered are thiophenyl ether disiloxanes and trisiloxanes.
Akawie, R. I., Bilow, N.
core   +1 more source

Chiral Modification of the Tetrakis(pentafluorophenyl)borate Anion with Myrtanyl Groups [PDF]

, 2019
The synthesis and characterization of chiral [B(C6F5)4]– derivatives bearing a myrtanyl group instead of a fluoro substituent in the para position are described.
Oestreich, Martin, Pommerening, Phillip
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source