Results 51 to 60 of about 18,438,198 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Preparation of low-oxygen titanium powder by magnesiothermic reduction of TiO2 in KCl–MgCl2–YCl3 molten salt

Journal of Materials Research and Technology, 2023
The Kroll process is currently the only effective method in industry to produce sponge titanium with a low-oxygen concentration (500 ppm). However, it has several limitations, such as a long processing time, low efficiency, and high energy consumption ...
Liguo Zhu, Lingxin Kong, Chonglin Bai, Baoqiang Xu, Bin Yang   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A clean and short process for the preparation of refined indium and investigation of migration distribution pattern of impurities thallium and tin via vacuum distillation

Journal of Materials Research and Technology
In this study, a novel two-stage vacuum distillation method was proposed to refine crude indium to prepare refined indium. Low-temperature distillation (1223K, holding time of 3h) and high-temperature distillation (1473K, holding time of 5h) were ...
Liangliang Chen, Yanan Wang, Lingxin Kong, Baoqiang Xu, Bin Yang   +4 more
doaj   +1 more source

False vacuum as an unstable state [PDF]

EPJ Web of Conferences, 2016
Calculations performed within the Standard Model suggest that the electroweak vacuum is unstable if MH < 126 GeV, (MH is the mass of the Higgs particle). LHC discovery of the Higgs boson indicates that MH ≃ 125 GeV. So the vacuum in our Universe may be unstable.
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Extremal vacuum black holes in higher dimensions [PDF]

, 2008
We consider extremal black hole solutions to the vacuum Einstein equations in dimensions greater than five. We prove that the near-horizon geometry of any such black hole must possess an SO(2, 1) symmetry in a special case where one has an enhanced ...
Figueras, Pau, Rangamani, Mukund, Lucietti, James, Kunduri, Hari K.   +3 more
core   +1 more source

Vacuum states for compressible flow

Discrete and Continuous Dynamical Systems, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Liu, Tai-Ping, Xin, Zhouping, Yang, Tong
openaire   +2 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source