Results 41 to 50 of about 1,604 (198)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Effect of secondary swirl in supersonic gas and plasma flows in the self-vacuuming vortex tube
MATEC Web of Conferences, 2018 This article presents the results of simulation for a special type of vortex tubes – self-vacuuming vortex tube (SVT), for which extreme values of temperature separation and pressure drop are realized.
Volov Vyacheslav, Lyaskin Anton
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Lead Free Multilayer Piezoelectric Actuators by Economically New Approach
Frontiers in Materials, 2020 The replacement of lead zirconate titanate ceramics (PZTs), with a lead-oxide (PbO)-free alternative is the subject of intense investigation worldwide. In this research, a cheap reliable methodology for the fabrication of multilayers (MLs) of lead-free ...
Fayaz Hussain +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Can We Vacuum Our Air Pollution Problem Using Smog Towers?
Atmosphere, 2020 In November 2019, the Supreme Court of India issued a notification to all the states in the National Capital Region of Delhi to install smog towers for clean air and allocated INR 36 crores (~USD 5.2 million) for a pilot.
Sarath Guttikunda, Puja Jawahar
doaj +1 more source
Design, calculation and use of the multipurpose vacuum ground meat mixer
Vestnik MGTU, 2020 Ground meat mixers mixing minced muscle tissue with other pre-formulated ingredients, are among the most common types of specialized meat processing equipment. The quality of minced meat, this being a food dispersed medium, including a solid, liquid and,
Verbytskyi S. B. +2 more
doaj +1 more source