Smart Medicine, Volume 4, Issue 2, June 2025.Molecular target engagements and metabolic changes reveal that NSC48160 inhibits the progression of HCC through ferroptosis. NSC48160 elucidates the ferroptosis mechanism whereby it impedes KRAS and instigates the downregulation of Nrf2/SLC7A11/GPX4.
Jiaxin Zhang +5 more
wiley +1 more source
Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy
VIEW, Volume 6, Issue 3, June 2025.The effects of semaglutide on IR, mitochondrial dynamics, and mitophagy in the hippocampus of BCAS mice after CCH. It was shown that semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving IR and passing through GLP‐1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery
Xiaoyan Yang +11 more
wiley +1 more source
Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells. [PDF]
World J Gastrointest OncolHou YX +5 more
europepmc +1 more source
Weak Supervision: A Survey on Predictive Maintenance
WIREs Data Mining and Knowledge Discovery, Volume 15, Issue 2, June 2025.The authors conduct a comprehensive examination of Weakly Supervised Learning for Predictive Maintenance, the survey discusses the challenges and identifies open research lines. ABSTRACT The maintenance advancements achieved in Industry 4.0 generate large amounts of data, necessitating complete, accurate, and precise labels for training datasets to ...
Antonio M. Martínez‐Heredia +1 more
wiley +1 more source
Mechanical Circulatory Support in Congenital Heart Disease. [PDF]
Children (Basel)Lynch Á, Jeewa A.
europepmc +1 more source
Association of allostatic load with all-cause and cause-specific dementia: A prospective cohort study. [PDF]
Alzheimers Dement (N Y)Gou Y +9 more
europepmc +1 more source
Pump‐Induced Hemolysis of Speed Modulated Axial‐Flow Left Ventricular Assist Devices
Artificial Organs, Volume 49, Issue 6, Page 988-996, June 2025.Two Sputnik1 and two HeartMate2 axial‐flow LVADs were operated in hemolysis test benches under both constant speed and speed modulation modes (n = 7). One of the Sputnik1 pumps exhibited a statistically significant increase in hemolysis, while none of the HeartMate2 pumps showed statistically significant differences.
Patrick Borchers +3 more
wiley +1 more source
Loss of the vitamin A receptor RBPR2 in mice disrupts whole-body retinoid homeostasis and the quantitative balance regulating retinylidene protein synthesis. [PDF]
FASEB JRadhakrishnan R +4 more
europepmc +1 more source
Peritoneal Dialysis in Patients Supported by Left Ventricular Assist Device
Artificial Organs, Volume 49, Issue 6, Page 1062-1066, June 2025.Peritoneal Dialysis (PD) has advantages over hemodialysis, including fewer infections and the comfort of the ambulant setting. This study illustrates that PD in LVAD patients is feasible and long‐term support up to several years is achievable without significant complications.
Zurab Darbaidze +10 more
wiley +1 more source
Iron Overload, Microbleeding and the Role of Bilirubin in Alzheimer's Disease Brain: Revisiting the Vascular Hypothesis. [PDF]
Int J Mol SciFiciarà E +6 more
europepmc +1 more source