GGCT Inhibits Ferroptosis in PTC Cells by Upregulating p53 Through RPS15A
Our results showed that γ‐glutamine cyclotransferase (GGCT) knockdown in PTC cells inhibited GSH synthesis, promoted the malignant accumulation of malondialdehyde (MDA) and reactive oxygen species (ROS), and finally promoted cell ferroptosis. In vivo experiments showed that Pro‐GA, a specific inhibitor of GGCT, inhibited the subcutaneous tumorigenesis ...
Hui‐min Zhang+9 more
wiley +1 more source
Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology. [PDF]
Chen H, Zeng L.
europepmc +1 more source
Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death
()‐D‐Tox peptide binding to the ligands triggers their internalization via clathrin‐mediated endocytosis. Intracellular presence of ()‐D‐Tox peptide induces a transient loss of mitochondrial membrane integrity and oligomerization of MLKL. Translocation of the oligomers to the plasma membrane causes a leakage of the cytosolic content and ultimately ...
Maria F. Setiawan+2 more
wiley +1 more source
Gastrointestinal Bleeding During Long-Term Left Ventricular Assist Device Support: External Validation of UTAH Bleeding Risk Score. [PDF]
Vadalà G+11 more
europepmc +1 more source
Exploratory analysis of long-term suppressive therapy with dalbavancin in ventricular assist device infections caused by Staphylococcus aureus. [PDF]
Morath B+12 more
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Psychological support for an adolescent awaiting heart transplantation: A case report on psychological intervention using the Stanford Integrated Psychosocial Assessment for Transplant. [PDF]
Takano K+5 more
europepmc +1 more source
Voluntary Assisted Dying and Community Palliative Care: A Retrospective Study in Victoria, Australia. [PDF]
Molenaar R, Lee S, Lynch J, Rogerson K.
europepmc +1 more source
Pan-caspase inhibitor protects against noise-induced hearing loss in a rodent model. [PDF]
Yepes MF+4 more
europepmc +1 more source