Results 61 to 70 of about 416,851 (314)

Long-term impact of acyclovir suppressive therapy on genital and plasma HIV RNA in Tanzanian women: a randomized controlled trial.

, 2010
BACKGROUND: Herpes simplex virus (HSV) suppressive therapy reduces genital and plasma human immunodeficiency virus type 1 (HIV-1) RNA over periods up to 3 months, but the long-term effect is unknown.
Mugeye, Kokugonza, Changalucha, John, Weiss, Helen A, Watson-Jones, Deborah, Tanton, Clare, Hayes, Richard J, Baisley, Kathy, Clayton, Tim C, Rusizoka, Mary, Ross, David A, Everett, Dean, Legoff, Jerome, Belec, Laurent   +12 more
core   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Species-level classification of the vaginal microbiome [PDF]

, 2012
Background The application of next-generation sequencing to the study of the vaginal microbiome is revealing the spectrum of microbial communities that inhabit the human vagina.
Buck, Gregory A., Sheth, Nihar U., Brooks, J. Paul, Fettweis, Jennifer M., Jefferson, Kimberly K., Mayer, Carly M., Vaginal Microbiome Consortium, Vaginal Microbiome Consortium (additional members), Serrano, Myrna G., Glascock, Abigail L.   +9 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Prevalence of colonization by Streptococcus agalactiae among pregnant women in Bukavu, Democratic Republic of the Congo

Journal of Infection in Developing Countries, 2014
Introduction: Maternal vaginal colonization by Streptococcus agalactiae (GBS) has an important impact on neonatal health but has not been studied in the Democratic Republic of Congo.
Kashosi T Mitima, Steve Ntamako, Achippe M Birindwa, Ntakwinja Mukanire, John M Kivukuto, Kibendelwa Tsongo, Kanigula Mubagwa   +6 more
doaj   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

The overlooked role of the seminovaginal microbiota in infertility: a narrative mini review

Frontiers in Medicine
Infertility affects up to 15% of couples worldwide and is influenced by complex biological, immunological, and environmental factors. While reproductive microbiome research has expanded rapidly, the majority of published studies remain largely ...
Charlotte Storck-Thy, Karen Angeliki Krogfelt, Rie Jønsson   +2 more
doaj   +1 more source

Phase I Randomised Clinical Trial of an HIV-1(CN54), Clade C, Trimeric Envelope Vaccine Candidate Delivered Vaginally. [PDF]

, 2011
We conducted a phase 1 double-blind randomised controlled trial (RCT) of a HIV-1 envelope protein (CN54 gp140) candidate vaccine delivered vaginally to assess immunogenicity and safety.
Fraser Carol A., Wiggins, RC, Cai Chun, David J Lewis, David J. Lewis, Maria Woodrow, Martin P. Cranage, Manoussaka, Maria, Wiggins Rebecca C., Giemza, Rafaela, Giemza Rafaela, Fraser, CA, Alethea Cope, Cai, Chun, Lacey, Charles J, Cranage Martin P., Cai, C, Cope Alethea, Abdel N Mahmoud, Cope, A, Tom Cole, Robin J Shattock, Jeffs, Simon A, Shattock, RJ, Rebecca C. Wiggins, Maria Manoussaka, Charles J Lacey, Charles J. Lacey, Manoussaka Maria, Cranage, Martin P, Cole Tom, Martin P Cranage, Lewis David J., Shattock, Robin J, Lacey, CJ, Jeffs Simon A., Woodrow, M, Manoussaka, M, Lewis, David J, Rafaela Giemza, Chun Cai, Mahmoud Abdel N., Robin J. Shattock, Wiggins, Rebecca C, Cole, Tom, Simon A. Jeffs, Shattock Robin J., Fraser, Carol A, Mahmoud, AN, Simon A Jeffs, Lewis, DJ, Giemza, R, Carol A Fraser, Woodrow, Maria, Jeffs, SA, Carol A. Fraser, Woodrow Maria, Cole, T, Cope, Alethea, Abdel N. Mahmoud, Mahmoud, Abdel N, Rebecca C Wiggins, Cranage, MP, Lacey Charles J.   +63 more
core   +2 more sources

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

CYSTOCELE REPAIR BY SYNTHETIC MESH SECURED THROUGH THE OBTURATOR FORAMEN (PERIGEE SYSTEM) [PDF]

, 2008
Cilj rada. Prikazati preliminarne rezultate transobturatornog pristupa korekcije cistocela metodom Perigee. Metode. 22 bolesnice s cistocelom drugog stupnja podvrgnute su u našoj ustanovi metodi Perigee u vremenskom razdoblju između sječnja 2006.
Župić, Tomislav, Lovrić, Helena, Orešković, Slavko, Kalafatić, Držislav, Banović, Maja, Gojević, Ante   +5 more
core   +1 more source