Results 61 to 70 of about 9,676,443 (329)

The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions

Nature Communications, 2020
Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain.
A. Mitra, D. MacIntyre, G. Ntritsos, Ann Smith, K. Tsilidis, J. Marchesi, P. Bennett, A. Moscicki, M. Kyrgiou   +8 more
semanticscholar   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Pembrolizumab in Vaginal Carcinoma: A Case Report and Review of the Literature

Case Reports in Oncology
Introduction: Vaginal cancer is a rare gynecologic malignancy. While in a localized disease, concurrent chemoradiation grants local control and better overall survival, in a metastatic setting, the management options are very limited.
Maria Giuseppa Vitale, Cecilia Nasso, Beatrice Riccò, Alessandro Bocconi, Chiara Chiavelli, Cinzia Baldessari, Stefania Pipitone, Francesca Bacchelli, Laura Botticelli, Massimo Dominici, Roberto Sabbatini   +10 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

An unusual cause of postmenopausal vaginal haemorrhage: a case report

BMC Women's Health, 2019
Background Post-menopause vaginal haemorrhage is typically related to gynaecological malignancies. Bleeding from vaginal varices rarely occurs, especially in nonpregnant women.
Junyan Sun, Ying Guo, Li Ma, Zhaoxia Qian, Dongmei Lai   +4 more
doaj   +1 more source

Vaginal lesion as first manifestation of colorectal disease

Revista Española de Enfermedades Digestivas, 2022
A 73-year-old woman presented at Gyneacology Consultation with vaginal sensation of a lump. Physical examination revealed a vaginal exophytic lesion with 3 cm located at the right inner lip. The lesion was biopsied and histologic examination revealed infiltration by a mucinous adenocarcinoma.
Mafalda, João, Inês, Viegas, Luís, Elvas, Ana Teresa, Cadime   +3 more
openaire   +2 more sources

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Vaginal candidosis: the place of butоconazol in pharmacotherapy

Гинекология, 2013
Vaginal candidosis is very common disease. To assess butоconazol therapeutical efficacy in treatment of chronic vaginal candidosis 58 patients in age of 22–48 years were examined.
G S Bogdanova, Z S Zaidieva, V A Zayakin
doaj  

Asymptomatic vaginal disease in pregnancy.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974
Asymptomatic Trichomonas vagina/is, candidiasis and Haemophi/us vagina/is were found to affect approximately 20% of women attending an antenatal clinic for the first time. Eight patients (1,4%) had asymptomatic gonorrhoea. Clinical features, such as pruritus and the appearance of a discharge, were frequently misleading, whereas examination of routine ...
Notelovitz, M., Massel, P., Jones, W.
openaire   +3 more sources