Results 171 to 180 of about 9,384,833 (391)
Clinical Pharmacology &Therapeutics, EarlyView.A common issue in clinical drug development involves drug–drug interactions (DDI) that may lead to altered drug exposure and subsequent altered safety and efficacy of an investigational drug or concomitant medications (conmeds) in the target patient population.
Alice S. Tang +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Over 10 million children in the world have epilepsy, with an unknown cause in half of the cases. The gut microbiome has been associated with various neurological disorders, and certain drugs greatly disturb the microbiome. Our aim was to study the association of prenatal and childhood exposure (before the age of two) to antibiotics, proton pump ...
Unnur Gudnadottir +4 more
wiley +1 more source
A New Approach to Compositional Data Analysis using \(L^{\infty}\)-normalization with Applications to Vaginal Microbiome [PDF]
arXivWe introduce a novel approach to compositional data analysis based on $L^{\infty}$-normalization, addressing challenges posed by zero-rich high-throughput data. Traditional methods like Aitchison's transformations require excluding zeros, conflicting with the reality that omics datasets contain structural zeros that cannot be removed without violating ...
arxiv
Meta-analysis of Gene Expression in Neurodegenerative Diseases Reveals Patterns in GABA Synthesis and Heat Stress Pathways [PDF]
arXiv, 2019 Neurodegenerative diseases are characterized as the progressive loss of neural cells, e.g. neurons, glial cells. Ageing, monogenic variations, viral infections, and many other factors are determined and speculated as causes for them. While many individual genes, such as APP for Alzheimer disease and HTT for Huntington disease, and biological pathways ...
arxiv
P142: Usefulness of vaginal ultrasonography in diagnosis of the endometrial diseases in postmenopausal obese women [PDF]
, 2003 A. Obr�bowska +3 more
openalex +1 more source
Biology and Management of Male‐Bodied Athletes in Elite Female Sports
Drug Testing and Analysis, EarlyView.Graphical representation of the relationships of transgender and XY DSDF as male‐bodied athletes along the binary dimensions of biological sex. ABSTRACT The physical advantages in elite power sports that allow men to surpass women are derived from the experience of male puberty.
David J. Handelsman, Stéphane Bermon
wiley +1 more source
Snap and Diagnose: An Advanced Multimodal Retrieval System for Identifying Plant Diseases in the Wild [PDF]
arXivPlant disease recognition is a critical task that ensures crop health and mitigates the damage caused by diseases. A handy tool that enables farmers to receive a diagnosis based on query pictures or the text description of suspicious plants is in high demand for initiating treatment before potential diseases spread further.
arxiv
Women associated vaginal symptoms with disease and sexual infidelity [PDF]
, 2004 Lenore Riddell
openalex +1 more source
Epilepsia Open, EarlyView.Abstract Objective To summarize the clinical features of collagen type IV alpha 1/2 chain (COL4A)1/2‐related epilepsy and the seizure outcomes of patients undergoing epilepsy surgery. Methods We retrospectively analyzed the clinical, electroencephalography, and neuroimaging data; genetic characteristics; surgical details; and prognosis of 8 patients (4
Jie Shi +12 more
wiley +1 more source
Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells
Cell Reports, 2020 Summary: The intact vaginal epithelium is essential for women’s reproductive health and provides protection against HIV and sexually transmitted infections. How this epithelium maintains itself remains poorly understood.
Ayesha Ali +5 more
doaj