Results 101 to 110 of about 1,994 (235)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tropical cyclone activity predicts autumn vagrancy of Nearctic birds on a remote North Atlantic island. [PDF]

BMC Zool
Monticelli D.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Uncovering genetic population structure in the Endangered northern rockhopper penguin (Eudyptes moseleyi) across islands in the Southern Atlantic and Indian oceans. [PDF]

BMC Genomics
Ritchie-Parker H, Ball A, Glass T, Costanzi JM, Boulinier T, Gamble A, Ghazali M, Keegan K, Barbraud C, Bost C, Bost C, Cleeland J, Clessin A, Connan M, Delord K, Dilley B, Glass T, Jones CW, Moore P, Lawrence K, LeBouard F, Osborne A, Phillips RA, Ratcliffe N, Repetto J, Risi M, Ryan PG, Spolander B, Swain S, Swain W, Tornos J, Whittle A, Senn H, Steinfurth A.   +33 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

14,15-dihydroclerodin (C₂₄H₃₆O₇) induced cell cycle delay, antimitotic and cytotoxic effects in Allium cepa L. root tip cells. [PDF]

Sci Rep
Ghosh P, Roy S, Ray S.
europepmc   +1 more source

Findings of new phytoplankton species in the Barents Sea as a consequence of global climate changes. [PDF]

PeerJ, 2023
Makarevich P, Larionov V, Oleinik A, Vashchenko P.   +3 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Updated checklist of the vertebrate fauna of the Doñana Biosphere Reserve, Spain. [PDF]

Zookeys
Román J, Arias AM, Arroyo JL, Bastianelli G, Calzada J, Clavero M, Cobo MD, Díaz-Paniagua C, Ibañez C, Juste J, Martínez A, Nogueras J, de Los Reyes L, Revilla E, Rodríguez R, Rodríguez-Rodríguez EJ, Del Valle JL, Janss GFE, Tablado Z, D'Amico M, Navarro LM.   +20 more
europepmc   +1 more source