Results 221 to 230 of about 5,384 (285)

Establishment and population expansion of the non-native Azores chromis (Chromis limbata) in the subtropical southwestern Atlantic. [PDF]

J Fish Biol
Munhoz RR, Athayde ACS, Pimentel CR, Rolim FA, Pereira-Filho GH, Dos Santos Motta F.   +5 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

The cytotoxic, genotoxic and mitotoxic effects of <i>Atractylis gummifera</i> extract in vitro. [PDF]

Afr Health Sci
Boumaza A, Ergüç A, Orhan H.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

ArtifactOps and ArtifactDL: a methodology and a language for conceptualizing and operationalising different types of pipelines. [PDF]

J Cloud Comput (Heidelb)
Miñón R, Diaz-de-Arcaya J, Torre-Bastida AI, López-de-Armentia J, Zarate G, Bonilla L, Garcia-Perez A, Aguirre-Usandizaga J.   +7 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Phenolic profile and protective role of Calendula officinalis against molybdenum-induced toxiciy in Allium cepa. [PDF]

Sci Rep
Kutluer F.
europepmc   +1 more source

Genotoxic effects of NDMA-contaminated ranitidine on Allium cepa cells and unveiling carcinogenic mechanisms via DFT and molecular dynamics simulation study. [PDF]

Sci Rep
Kaly MK, Rahman ME, Rana MS, Acharjee UK, Nasirujjaman K.   +4 more
europepmc   +1 more source

First Bisexually Dimorphic Phytoptid Taxon (Eriophyoidea, Phytoptidae) from Gondwanian Angiosperm Host. [PDF]

Animals (Basel)
Chetverikov PE, Peralta Alba LE.
europepmc   +1 more source