Results 131 to 140 of about 872,914 (309)

Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome

Epilepsia, EarlyView.
Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan, Kette Valente, Vicente Villanueva, Adam Strzelczyk, Rima Nabbout, Eiji Nakagawa, Yuehua Zhang, Marta Zolnowska, Yasir Khan, Cheng Dong, Samuel Hsiao, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Venkatesha Murthy   +14 more
wiley   +1 more source

Executive dysfunction and employment in epilepsy

Epilepsia, EarlyView.
Abstract Objective Executive dysfunction, affective symptoms, and unemployment are prevalent in patients with epilepsy, yet the relation between these variables remains poorly understood. The present study examined: (1) The relationship between epilepsy‐related variables, affective symptoms, and executive functions (EFs); and (2) how these variables ...
Lisa E. Hauger, Christoph Helmstaedter, Morten I. Lossius, Kristin Å. Alfstad, Ellen Molteberg, Halvor Torgersen, Annette H. Skogan   +6 more
wiley   +1 more source

Agreement and 2‐year trajectories of youth‐ and parent‐reported health‐related quality of life in youth with epilepsy treated with surgery vs medical therapy

Epilepsia, EarlyView.
Abstract Objective This cohort study examined the agreement between youth‐ and parent‐reported health‐related quality of life (HRQOL) of children treated with epilepsy surgery compared to medical therapy. A second aim was to evaluate whether changes in HRQOL over 2 years differed between the two groups, and to determine whether these trajectories ...
Mary Lou Smith, Klajdi Puka, Elysa Widjaja   +2 more
wiley   +1 more source

Human vagus nerve fascicular anatomy and its implications for targeted cardiac stimulation: a microCT segmentation and histological pilot anatomical study

Frontiers in Neuroscience
IntroductionThe functional anatomy of autonomic nerve fascicles has remained poorly understood. Building on prior evidence of organotopic organization in the pig cervical vagus nerve, this study examined the thoracic branches of the human vagus nerve ...
Nicole Thompson, Svetlana Mastitskaya, Francesco Iacoviello, Felicia Turhani, Paul R. Shearing, Kirill Aristovich, David Holder   +6 more
doaj   +1 more source

Deep brain stimulation of the thalamus for intractable epilepsy (FRANCE study): A randomized clinical trial

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the efficacy and safety of deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) compared with best medical treatment (BMT) in patients with drug‐resistant epilepsy (DRE).
Stéphan Chabardès, Fabrice Bartolomei, Anca Nica, Claire Haegelen, Lorella Minotti, Brigitte Piallat, Chrystele Mosca, Sandrine Massicot, Sylvain Rheims, Marc Guenot, Emmanuel Cuny, Jérome Aupy, Louis Maillard, Sophie Colnat‐Coulbois, Corentin Leroy, Romain Carron, Philippe Coubes, Philippe Gélisse, Carine Karachi, Vincent Navarro, Bertrand Devaux, Francine Chassoux, Phlippe Derambure, Nicolas Reyns, Jean Christope Sol, Luc Valton, Denys Fontaine, Veronique Bourg, Philippe Kahane, Sandra David‐Tchouda, Jean Regis   +30 more
wiley   +1 more source

Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice

Nature Communications
The vagus nerve crucially affects emotions and psychiatric disorders. However, the detailed neurophysiological dynamics of the vagus nerve in response to emotions and its associated pathological changes remain unclear. In this study, we demonstrated that
Toya Okonogi, Nahoko Kuga, Musashi Yamakawa, Tasuku Kayama, Yuji Ikegaya, Takuya Sasaki   +5 more
doaj   +1 more source

Delayed and deferred surgery associated with cenobamate use in people with drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Cenobamate has been shown to be an effective antiseizure medication for some patients with drug‐resistant focal epilepsy being considered for epilepsy surgery. This retrospective single‐center study evaluated whether surgery was obtained within 12 months for patients who received cenobamate as a treatment during the presurgical ...
Jacob Pellinen, Stefan Sillau, Aimee Bui, Alexandra Danciutiu, Lesley Kaye, Ashvin Sood, Louis Ferrari, William E. Rosenfeld, Christopher Elder   +8 more
wiley   +1 more source

Efficacy observation of combined transcutaneous vagus nerve stimulation and transcranial direct current stimulation on gait in 169 subacute stroke patients

Journal of Rehabilitation Medicine
Objective: To investigate the combined effect of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation on improving lower limb function in stroke patients. Design: Randomized controlled trial.
Litong Wang, Likai Wang, Zhan Wang, Hongyu Zhao, Jingyi Wu, Fei Gao, Hong Tang   +6 more
doaj   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Transcutaneous Auricular Vagus Nerve Stimulation to Improve Emotional State

Biomedicines
Emotional experiences are a part of our lives. The maladaptive functioning of an individual’s emotional field can lead to emotional disturbances of various kinds, such as anxiety and depression.
Ainara Aranberri Ruiz
doaj   +1 more source