Results 141 to 150 of about 244,927 (316)

Total Synthesis and Analysis of Phenolic Phytoprostanes, Oxidized Derivatives of Lipophenols

open access: yesChemistry – A European Journal, EarlyView.
The total synthesis of four hydroxytyrosol‐phytoprostanes (PhytoPs‐HT) was achieved in 20 steps, enabling their first identification as HT‐α‐linolenate oxidation products. This work revealed new oxidized derivatives of lipophenols via UHPLC‐MS/MS analysis, offering a strategy to trace HT‐derived compounds in complex matrices, aiding food and biomedical
M. Jordan Lehoux   +6 more
wiley   +1 more source

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

open access: yesChemMedChem, EarlyView.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez   +10 more
wiley   +1 more source

Micellar Liquid Chromatography Determination of Edoxaban in Oral Solid Dosage Forms: Theoretical Aspects and Validation

open access: yesChemMedChem, EarlyView.
A method is developed and validated to quantify edoxaban in solid oral dosage forms using micellar liquid chromatography. A chemometric strategy is used to study the retention mechanism. The procedure is green, economic, safe, and easy to handle; offers high sample throughput; and is reliable, thus useful for pharmaceutical quality control.
Juan Peris‐Vicente   +4 more
wiley   +1 more source

Influence of Ronchi Grating Orientation on Color Stimuli Bezold Effect

open access: yesColor Research &Application, EarlyView.
The Bezold effect, which refers to the influence of the shape and size of surrounding objects on the perceived color of a stimulus, has been studied. The aim of this study is to determine whether the orientation of the grating lines (horizontal or vertical) produces a significantly different variation in color appearance across different grating ...
Jorge Montalvá   +4 more
wiley   +1 more source

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