A Fluorogenic Biosensor for Direct Detection of Vibrio vulnificus, a Climate Change Biomarker. [PDF]
Nanoporous anodic alumina (S2) loaded with rhodamine B and capped with a specific oligonucleotide probe (O1) for the vvhA gene. In the presence of V. vulnificus genomic DNA, probe displacement opens the pores and releases the dye, generating a measurable fluorescent signal.
Aranda MN +8 more
europepmc +2 more sources
A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection. [PDF]
A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Domínguez M +13 more
europepmc +2 more sources
Response of Amblyseius swirskii to deltamethrin. [PDF]
The analysis of toxicological and molecular data reveals target‐site as well as metabolic modifications associated with the resistance to deltamethrin in Amblyseius swirskii colonies. However, semi‐field assays show increased run‐off behavior after treatments with the same pesticide.
Benavent-Albarracín L +5 more
europepmc +2 more sources
Bi-Functional Topospecific Nanoparticles to Promote Immune-Tumor Cell Engagement as A New Immunotherapeutic Strategy. [PDF]
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Ortuño-Bernal A +9 more
europepmc +2 more sources
Introduction: Congenital heart defects (CHDs) are the most prevalent and severe type of major congenital anomalies (CAs). The objective of this study was to determine the frequency and distribution of CHDs in the Valencian Region from 2007 to 2014 ...
María Pastor-García +4 more
doaj +1 more source
Boletín oficial de la provincia de León: Número 177 - 1971 agosto 6 [PDF]
Copia digital. Valladolid : Junta de Castilla y León.
León (Provincia). Diputación Provincial
core +5 more sources
Introducción: Los pacientes sometidos a Trasplante de Células Madre Hematopoyéticas o trasplante de médula padecen varias complicaciones nutricionales. El objetivo del estudio fue realizar una descripción prospectiva en estos pacientes.
Luis Cabañas Alite +5 more
doaj +1 more source
Cellular photo(geno)toxicity of gefitinib after biotransformation
Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer.
Meryem El Ouardi +9 more
doaj +1 more source
Optimized ACE2-Fc fusion proteins with picomolar neutralization activity against highly evolved SARS-CoV-2 variants. [PDF]
Abstract The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has compromised the efficacy of many authorized monoclonal antibody products. This highlights the need for alternative strategies, especially for vulnerable populations such as immunocompromised individuals.
Abancó F +16 more
europepmc +2 more sources
Sensitivity of precipitation forecasts to convective parameterization in the October 2007 Flash Flood in the Valencia Region (Eastern Spain) [PDF]
The Valencia region, on the Mediterranean coast of the Iberian Peninsula, is an area prone to torrential rains, especially the north of Alicante province and the south of Valencia province.
I. Gómez, F. Pastor, M. Estrela
doaj +1 more source

