Results 11 to 20 of about 782 (136)

A Fluorogenic Biosensor for Direct Detection of Vibrio vulnificus, a Climate Change Biomarker. [PDF]

Microbiologyopen
Nanoporous anodic alumina (S2) loaded with rhodamine B and capped with a specific oligonucleotide probe (O1) for the vvhA gene. In the presence of V. vulnificus genomic DNA, probe displacement opens the pores and releases the dye, generating a measurable fluorescent signal.
Aranda MN, Caballos I, López-Palacios A, Carmona-Salido H, Sanjuan E, Aznar E, Amaro C, Martínez-Máñez R, Hernández-Montoto A.   +8 more
europepmc   +2 more sources

A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection. [PDF]

Adv Sci (Weinh)
A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Domínguez M, Azorín-Soriano D, Lérida-Viso A, García-Fleitas J, Soriano-Teruel PM, Beatty JS, Rodrigo-Martínez P, Arroyo P, Rojas-Vázquez S, Fariñas I, Sancenón F, Blandez JF, García-Fernández A, Martínez-Máñez R.   +13 more
europepmc   +2 more sources

Mechanistic Insights Into the Photosensitizing Properties of the Topical Retinoid Tazarotene. [PDF]

ChemMedChem
Light‐activated retinoids: Tazarotene and its active metabolite tazarotenic acid form long‐lived triplet excited states upon UVA irradiation, generating singlet oxygen and promoting photochemical reactions. These processes correlate with reduced fibroblast viability under light exposure, revealing potential phototoxicity and implications for combined ...
Soler-Orenes JA, Dillon M, Rodríguez-Muñiz GM, Ansino-Ortiz M, Andreu I, Lhiaubet-Vallet V.   +5 more
europepmc   +2 more sources

Response of Amblyseius swirskii to deltamethrin. [PDF]

Pest Manag Sci
The analysis of toxicological and molecular data reveals target‐site as well as metabolic modifications associated with the resistance to deltamethrin in Amblyseius swirskii colonies. However, semi‐field assays show increased run‐off behavior after treatments with the same pesticide.
Benavent-Albarracín L, Pérez-Hedo M, Alonso-Valiente M, Catalán J, Urbaneja A, González-Cabrera J.   +5 more
europepmc   +2 more sources

Cambios en el estado nutricional, composición corporal y sintomatología asociada en pacientes hospitalizados sometidos a trasplante de médula ósea: estudio longitudinal prospectivo

Revista Española de Nutrición Humana y Dietética, 2020
Introducción: Los pacientes sometidos a Trasplante de Células Madre Hematopoyéticas o trasplante de médula padecen varias complicaciones nutricionales. El objetivo del estudio fue realizar una descripción prospectiva en estos pacientes.
Luis Cabañas Alite, José Miguel Soriano del Castillo, Juan Francisco Merino-Torres, Ana Isabel Catalá-Gregori, Jaime Sanz Caballer, José Luis Piñana   +5 more
doaj   +1 more source

Cellular photo(geno)toxicity of gefitinib after biotransformation

Frontiers in Pharmacology, 2023
Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer.
Meryem El Ouardi, Meryem El Ouardi, Lorena Tamarit, Lorena Tamarit, Ignacio Vayá, Ignacio Vayá, Miguel A. Miranda, Miguel A. Miranda, Inmaculada Andreu, Inmaculada Andreu   +9 more
doaj   +1 more source

Bi-Functional Topospecific Nanoparticles to Promote Immune-Tumor Cell Engagement as A New Immunotherapeutic Strategy. [PDF]

Adv Mater
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Ortuño-Bernal A, Clara-Trujillo S, Lucena-Sánchez E, Hicke FJ, Escudero A, Pradana-López S, Jiménez-Alduan N, Díez P, García-Fernández A, Martínez-Máñez R.   +9 more
europepmc   +2 more sources

Sensitivity of precipitation forecasts to convective parameterization in the October 2007 Flash Flood in the Valencia Region (Eastern Spain) [PDF]

Advances in Geosciences, 2010
The Valencia region, on the Mediterranean coast of the Iberian Peninsula, is an area prone to torrential rains, especially the north of Alicante province and the south of Valencia province.
I. Gómez, F. Pastor, M. Estrela
doaj   +1 more source

Dynamic Membranes for Enhancing Resources Recovery from Municipal Wastewater

Membranes, 2022
This paper studied the feasibility of using dynamic membranes (DMs) to treat municipal wastewater (MWW). Effluent from the primary settler of a full-scale wastewater treatment plant was treated using a flat 1 µm pore size open monofilament polyamide ...
Pau Sanchis-Perucho, Daniel Aguado, José Ferrer, Aurora Seco, Ángel Robles   +4 more
doaj   +1 more source

Optimized ACE2-Fc fusion proteins with picomolar neutralization activity against highly evolved SARS-CoV-2 variants. [PDF]

Protein Sci
Abstract The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has compromised the efficacy of many authorized monoclonal antibody products. This highlights the need for alternative strategies, especially for vulnerable populations such as immunocompromised individuals.
Abancó F, Tarrés-Freixas F, Lepore R, Molina-Molina E, Franco E, Boreika R, Pradenas E, Raïch-Regué D, Erkizia I, Clotet B, Valencia A, Vergara-Alert J, Segalés J, Carrillo J, Izquierdo-Useros N, Blanco J, Trinité B.   +16 more
europepmc   +2 more sources