Results 171 to 180 of about 5,297,983 (305)

Development and Validation of Prediction Models for the Prognosis of Clear Cell Adenocarcinoma of the Cervix: A Population-Based Cohort Study. [PDF]

Cancer Med
Chen L, Liu L, Lin F, Fu Y, Yang L, Sun Y.   +5 more
europepmc   +1 more source

Validation of biomarkers of aging

Nature Medicine
M. Moqri, Chiara M S Herzog, J. Poganik, Kejun Ying, Jamie N. Justice, D. Belsky, A. Higgins-Chen, Brian H. Chen, Alan A. Cohen, Georg Fuellen, S. Hägg, R. Marioni, Martin Widschwendter, Kristen Fortney, Peter O. Fedichev, Alex Zhavoronkov, N. Barzilai, J. Lasky-Su, D. Kiel, Brian K. Kennedy, Steven R Cummings, P. Slagboom, Eric Verdin, A. Maier, V. Sebastiano, Michael P. Snyder, V. Gladyshev, S. Horvath, L. Ferrucci   +28 more
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

External validation of a prognostic model predicting renal graft function one year after brain-dead donor kidney transplantation. [PDF]

Langenbecks Arch Surg
Tessmer P, Weigle CA, Meister FA, Wiemann BA, Gwinner W, Mühlfeld A, Kramann R, Kleine-Döpke D, Richter N, Oldhafer F, Vondran FWR, Schrem H, Beetz O, Zwirner U.   +13 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

An explainable and transparent machine learning approach for predicting dental caries: a cross-national validation study. [PDF]

BMC Oral Health
Tirkkonen O, Tiensuu H, Väyrynen E, Suutala J, Vuollo V, Laitala ML, Karki S.   +6 more
europepmc   +1 more source