Results 141 to 150 of about 7,539,132 (320)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Estimation of All-Sky Gridded Diurnal Near-Surface Air Temperatures at Regional Scale From FY-4B Measurements

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The near-surface air temperature (${{T}_{air}}$) is a principal variable describing energy exchange and water circulation between the land surface and the atmospheric environment. The estimation of ${{T}_{air}}$ by satellite land surface temperature (LST)
Ronghan Xu, Xin Wang, Yonghong Hu, Lin Chen, Suling Ren, Guangzhen Cao, Di Xian, Eston Ranson Mogha   +7 more
doaj   +1 more source

Some Theory For Practical Classifier Validation [PDF]

arXiv, 2015
We compare and contrast two approaches to validating a trained classifier while using all in-sample data for training. One is simultaneous validation over an organized set of hypotheses (SVOOSH), the well-known method that began with VC theory. The other is withhold and gap (WAG).
arxiv  

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Distribution Learning with Valid Outputs Beyond the Worst-Case [PDF]

arXiv
Generative models at times produce "invalid" outputs, such as images with generation artifacts and unnatural sounds. Validity-constrained distribution learning attempts to address this problem by requiring that the learned distribution have a provably small fraction of its mass in invalid parts of space -- something which standard loss minimization ...
arxiv  

An extreme function which is nonnegative and discontinuous everywhere [PDF]

arXiv, 2018
We consider Gomory and Johnson's infinite group model with a single row. Valid inequalities for this model are expressed by valid functions and it has been recently shown that any valid function is dominated by some nonnegative valid function, modulo the affine hull of the model.
arxiv  

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Accurate Satellite Operation Predictions Using Attention-BiLSTM Model with Telemetry Correlation

Aerospace
In satellite health management, anomalies are mostly resolved after an event and are rarely predicted in advance. Thus, trend prediction is critical for avoiding satellite faults, which may affect the accuracy and quality of satellite data and even ...
Yi Peng, Shuze Jia, Lizi Xie, Jian Shang
doaj   +1 more source

Validity in Design Science [PDF]

arXiv
Researchers must ensure that the claims about the knowledge produced by their work are valid. However, validity is neither well-understood nor consistently established in design science, which involves the development and evaluation of artifacts (models, methods, instantiations, and theories) to solve problems.
arxiv  

Optimizing Validation Phase of Hyperledger Fabric [PDF]

arXiv, 2019
Blockchain technologies are on the rise, and Hyperledger Fabric is one of the most popular permissioned blockchain platforms. In this paper, we re-architect the validation phase of Fabric based on our analysis from fine-grained breakdown of the validation phase's latency.
arxiv