Results 161 to 170 of about 9,445,211 (322)

Prediction models of adverse outcomes following surgery and radiotherapy for breast cancer: a systematic review. [PDF]

ESMO Real World Data Digit Oncol
Asfour H, Wang B, Zhou H, Al Janapy A, Patel NG, Symonds RP, Talbot CJ, Rattay T.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Measurement validity --- construct validity

, 2019
Presentation in WF ED 540, Data Analysis in Workforce Education & Development, at Penn State during Fall Semester ...
openaire   +1 more source

Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus.

Arthritis & Rheumatism, 2012
M. Petri, A. Orbai, Graciela S. Alarcón, C. Gordon, Joan T. Merrill, P. Fortin, I. Bruce, D. Isenberg, Daniel J. Wallace, O. Nived, G. Sturfelt, R. Ramsey‐Goldman, S. Bae, J. Hanly, J. Sánchez-Guerrero, A. Clarke, C. Aranow, S. Manzi, M. Urowitz, D. Gladman, K. Kalunian, M. Costner, V. Werth, A. Zoma, S. Bernatsky, G. Ruiz-Irastorza, M. Khamashta, S. Jacobsen, J. Buyon, P. Maddison, M. Dooley, R. V. van Vollenhoven, E. Ginzler, T. Stoll, C. Peschken, J. Jorizzo, Jeffrey P. Callen, S. S. Lim, B. Fessler, M. Inanç, D. Kamen, Anisur Rahman, K. Steinsson, Andrew G. Franks, L. Sigler, S. Hameed, H. Fang, N. Pham, R. Brey, M. H. Weisman, G. McGwin, L. Magder   +51 more
semanticscholar   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Fingerprints Encode Risk for Bipolarity. [PDF]

Bipolar Disord
Salvador R, García-León MÁ, Rodriguez-Jimenez R, Del Olmo-Encabo P, Barbosa L, Aquino-Servín A, Sotero-Moreno A, Fatjó-Vilas M, Jaurrieta-Guarner N, Sánchez M, Corte-Souto C, Rojo A, Rebolleda-Gil C, Correa-Ghisays P, Balanzá-Martínez V, Caride-Padilla C, Sarró S, Feria-Raposo I, Sánchez-Cabezudo Á, Jiménez-Rodríguez O, Torres ML, Moreno-Comellas R, Navarro B, Del Olmo-Romero F, Larraz-Romeo JA, Pomarol-Clotet E.   +25 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source