Results 211 to 220 of about 6,125,000 (281)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Accuracy of Machine Learning in Identifying Drug Resistance in Tuberculosis: A Systematic Review and Meta-Analysis. [PDF]

Health Sci Rep
Wei X, Norsuddin NM, Hamid HBA, Azmi MI, Zhang G, Tian J.   +5 more
europepmc   +1 more source

Comorbidity in multiple sclerosis patients from Nordland County, Norway – validated data from the Norwegian Patient Registry

, 2020
Espen Benjaminsen, Kjell‐Morten Myhr, Nina Grytten, Karl Bjørnar Alstadhaug   +3 more
openalex   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Design and validation of a clinical whole genome sequencing-based assay for patient screening in a large healthcare system. [PDF]

Front Mol Biosci
Wagner JT, Welle JT, Lucas Beckett IA, Emery KR, Cosgrove BA, Olszewski K, Wagner N, Bower TC, Yuan LC, Shull EM, Jade K, Clemens J, Magis AT, Campbell MB, Gordon OK, Bifulco CB, Piening BD.   +16 more
europepmc   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Research on grape leaf classification based on optimized densenet201 model. [PDF]

PLoS One
Huang J.
europepmc   +1 more source

A Validated HPLC-MS/MS Method for Simultaneous Determination of Militarine and Its Three Metabolites in Rat Plasma: Application to a Pharmacokinetic Study [PDF]

, 2019
Hui-Yuan Sun, Lin Zheng, Zipeng Gong, Yueting Li, Chang Yang, Jie Pan, Yong‐Lin Wang, Aimin Wang, Yongjun Li, Yong Huang   +9 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Real-time detection of respiratory circuit events in mechanical ventilation using deep learning. [PDF]

NPJ Digit Med
He Q, Pan T, Hou H, Yu Y, Chen G, Zhang L, Yan X, Niu L, Yang Y, Lv N, Tan R, Qu H.   +11 more
europepmc   +1 more source