Results 251 to 260 of about 6,428,897 (326)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The efficacy and safety of lower-dose aspirin for primary and secondary prevention of cardiovascular disease in the elderly: an interim analysis of a multicenter, prospective, observational study. [PDF]

Front Cardiovasc Med
Wang X, Qi H, Wu Y, Cong H, Hao P, Liu X, Liu Y, Yao Z, Jin A, Hou Y, He N, Zhao Y, Sun Y, Qian X, Liang K, Zhang H, Liu L, Zhang Z, Liu Y, Dou P, Xia S, Li H, Yang J, Hu J, Xia Z, Liu B, Jin H, Yan X, Miao W, Guo H, Zhao L, Zhang Q, Tian T, Sun X, He J, Chen X, Wang Z, Zhang Z, Liu Q, Wang J, Zhu S, Liu M.   +41 more
europepmc   +1 more source

Scalable discovery and validation of order-specific EHR event trajectories for interpretable adverse-outcome risk estimation (Supplementary Data)

Brice Edelman, Jeffrey Skolnick
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Development and validation of an LDCT-based deep learning radiomics nomogram for predicting postoperative recurrence of stage Ia lung adenocarcinoma. [PDF]

Front Oncol
Lan H, Wei C, Luo Y, Liao M, Liang H, Qin J, Yi J, Xu F, Huang D, Zhang M, Feng Q, Li T.   +11 more
europepmc   +1 more source

Validating A Prophetic-Based Assessment Model for Teacher Personality Competence

Atim Rinawati, Siti Fatimah
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The Role of Digital Games in Children’s Life: Development and Validation of a Likert-Type Scale for Gifted Students

Fatih Pala
openalex   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source