Results 251 to 260 of about 6,125,000 (281)

Prediction accuracy for feed intake and body weight gain using host genomic and rumen metagenomic data in beef cattle. [PDF]

Genet Sel Evol
Lakamp A, Adams S, Kuehn L, Snelling W, Wells J, Hales K, Neville B, Fernando S, Spangler ML.   +8 more
europepmc   +1 more source

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

Molecular Oncology, EarlyView.
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley   +1 more source

Diagnosing autism spectrum disorder based on eye tracking technology using deep learning models. [PDF]

Front Med (Lausanne)
Al-Adhaileh MH, Alsubari SNM, Al-Nefaie AH, Ahmad S, Alhamadi AA.   +4 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Genomic prediction and association mapping of early season flood tolerance in soybean. [PDF]

Plant Genome
Vieira CC, Wu C, Harrison D, Marmo R, Florez-Palacios L, Acuna A, Rogers D, Fernandes SB, Fernandes I, Shannon G, Ye H, Nguyen HT.   +11 more
europepmc   +1 more source

Validation of a Machine Learning Algorithm, EVendo, for Predicting Esophageal Varices in Hepatocellular Carcinoma

Jamie O. Yang, Punya Chittajallu, Jihane N. Benhammou, Arpan Patel, Joseph R. Pisegna, James H. Tabibian, Tien S. Dong   +6 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Strain release through hydrogen bond-mediated layer twisting. [PDF]

Sci Adv
Zheng Q, Li B, Liu S, Cao C, Rimsza JM, Zhang Q, Bai J, Chang C, Wang J, Liang C, Mao H, Carbone MR, Lu D, Pyatina T, Zheng H.   +14 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Models for predicting the risk of bloodstream infections associated with peripherally inserted central venous catheters: A scoping review. [PDF]

PLoS One
Cao L, Tao Y, Lei S, He S, Peng Y, Liu S, Chen H, Zhou J, Liu Y.   +8 more
europepmc   +1 more source