Results 221 to 230 of about 52,085,429 (356)

Assessment of 24-hour physical behaviour in adults via wearables: a systematic review of validation studies under laboratory conditions. [PDF]

Int J Behav Nutr Phys Act, 2023
Giurgiu M, Ketelhut S, Kubica C, Nissen R, Doster AK, Thron M, Timm I, Giurgiu V, Nigg CR, Woll A, Ebner-Priemer UW, Bussmann JBJ.   +11 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

[Equivalence and agreement in validation studies: A practical methodological review]. [PDF]

Rev Med Inst Mex Seguro Soc
Dell'Era S, Pagotto V.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Multi-omics and experimental validation studies reveal key biomarkers of cellular senescence in diabetic retinopathy. [PDF]

Diabetol Metab Syndr
Li J, Yang H, Lin Y, Fang Z.
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Pilot-scale depuration demonstrates the suitability of non-pathogenic Vibrio parahaemolyticus as a surrogate for commercial-scale validation studies. [PDF]

PLoS One
Lunda SL, Kilgore S, Hesser JM, Waite-Cusic JG, Schubiger CB.   +4 more
europepmc   +1 more source

Mapping QTLs and gene validation studies for Mg²⁺ uptake and translocation using a MAGIC population in rice. [PDF]

Front Plant Sci, 2023
Zhi S, Zou W, Li J, Meng L, Liu J, Chen J, Ye G.   +6 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Clinical prognostic models for sarcomas: a systematic review and critical appraisal of development and validation studies. [PDF]

Diagn Progn Res
Heesen P, Christ SM, Ciobanu-Caraus O, Kahraman A, Schelling G, Studer G, Bode-Lesniewska B, Fuchs B.   +7 more
europepmc   +1 more source