Results 241 to 250 of about 914,578 (282)

Microbiological/clinical characteristics and validation of topical therapy with kanamycin in aerobic vaginitis: a pilot study

International Journal of Antimicrobial Agents, 2004
The term 'aerobic vaginitis' defines a 'new' vaginal pathology that is neither classifiable as specific vaginitis nor as bacterial vaginosis. We studied a sample of 30 women with a clinical and microbiological diagnosis of aerobic vaginitis and compared the efficacy and tolerability of kanamycin and meclocycline, two products commercially available in ...
TEMPERA, Gianna, BONFIGLIO G, CAMMARATA E, CORSELLO S, CIANCI, Antonio   +4 more
openaire   +3 more sources

ADVANCED HPLC METHOD DEVELOPMENT, VALIDATION AND FORCE DEGRADATION STUDY FOR SIMULTANEOUS ANALYSIS OF ALLANTOIN, HYDROQUINONE AND TRETENOIN IN MELASMA TOPICAL CREAM FORMATION

Indian Drugs, 2022
A simple, sensitive, rapid, precise and accurate RP-HPLC method has been developed for simultaneous estimation of hydroquinone, allantoin and tretinoin from cream formulation. Chromatographic separation was achieved on a reversed-phase Inertsil C18 (4.6 mm) I.D.× 250 mm, 5 µm) column using a mobile phase consisting of buffer (pH 3.5) 0.05 M potassium ...
Raksha Shilu, Pankaj Kapupara
openaire   +1 more source

Validating topical skin therapies in randomised controlled studies

Veterinary Record, 2012
TOPICAL therapy has played an important role in the management of allergic and infectious skin diseases in human medicine for a long time (Callen and others 2007, Simpson 2010). There are many different topical vehicles and modes of application: sprays, lotions, gels, creams and ointments. As dogs are, in contrast to people, so much hairier and lesions
openaire   +2 more sources

ECVAM's Research and Validation Activities in the Fields of Topical Toxicity and Human Studies

Alternatives to Laboratory Animals, 2002
This paper outlines the research, prevalidation and validation activities that ECVAM has undertaken in collaboration with its partners in the field of topical toxicity testing and human volunteer studies, from its creation until now (1994–2002).
openaire   +2 more sources

Application of the Food and Drug Administration (FDA) bioequivalent guidance of topical dermatological corticosteroid in yellow‐skinned Japanese population: Validation study using a chromameter

The Journal of Dermatology, 2006
ABSTRACTThe American Food and Drug Administration (FDA) bioequivalent guidance of topical dermatological corticosteroids in 1995 (the Guidance) requires measurement of the skin blanching response with a chromameter for evaluation of cutaneously applied corticosteroid formulations.
Tomoko, Keida, Nobukazu, Hayashi, Makoto, Kawashima   +2 more
openaire   +2 more sources

Current challenges for FDA‐regulated bioanalytical laboratories performing human BA/BE studies; Part III: selected discussion topics in bioanalytical LC/MS/MS method validation

The Quality Assurance Journal, 2009
AbstractThis article is the third of a three‐part series that deals with current compliance issues/challenges for bioanalytical laboratories performing analysis for bioavailability (BA)/bioequivalence (BE) studies. Part 1 of this series discusses the application of key elements from the FDA Good Laboratory Practices (GLP) and the current Good ...
Frank Chow, Arlene Ocampo, Paul Vogel, Steven Lum, Nhan Tran   +4 more
openaire   +1 more source