Results 51 to 60 of about 252,061 (302)

The identification of psychological research topics with Topic Modeling [PDF]

, 2020
Vor dem Hintergrund eines fachlichen und gesellschaftlichen Interesses an psychologischen Forschungsthemen wurde der Einsatz von Topic Modeling zu deren automatisierten und validen Identifikation erprobt und mit einem traditionellen Ansatz verglichen ...
Bittermann, André (Dipl.-Psych.)
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Psychometric Evaluation of the Farsi Version of the Perceived Spiritual Support Scale Among Iranian Dental Professionals [PDF]

Health, Spirituality and Medical Ethics
Background and Objectives: Perceived spiritual support is increasingly recognized as a resilience resource for healthcare professionals. However, no validated Persian instrument exists to measure this construct among Iranian dental practitioners and ...
Roya Hamedi, Soodeh Tahmasbi, Zahra Taheri-Kharameh   +2 more
doaj  

Translation and validation of the Brazilian Portuguese version of the quality of life vascular access device questionnaire for chemotherapy patients [PDF]

Einstein (São Paulo)
Background: The use of long-term devices for chemotherapy in neoplastic diseases is very common. The CAVA trial was an extensive study that prospectively evaluated more than 1000 patients undergoing chemotherapy and randomly allocated them to three ...
Bruno Jeronimo Ponte, Carolina Carvalho Jansen Sorbello, Ricardo Ferreira Mendes de Oliveira, Maria Fernanda Cassino Portugal, Andressa Cristina Sposato Louzada, Marcelo Fiorelli Alexandrino da Silva, Lucas Lembrança Pinheiro, Cynthia de Almeida Mendes, Nelson Wolosker   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Reliability and validity in comparative studies of software prediction models

, 2005
Empirical studies on software prediction models do not converge with respect to the question "which prediction model is best?" The reason for this lack of convergence is poorly understood.
I. Myrtveit, E. Stensrud, Myrtveit, I, Shepperd, MJ, Stensrud, E, M. Shepperd   +5 more
core   +1 more source

A Synthesis of Algorithms for Multi-Jurisdiction Research in Canada.

International Journal of Population Data Science, 2022
Objectives Validation of algorithms to identify health conditions (e.g., diabetes) or service use (e.g., high-cost users) in administrative data is time-consuming and expensive. Many algorithms are only assessed in a single jurisdiction, which may limit
Lisa Lix, Viktoriya Vasylkiv, Olawale Ayilara, Lindsey Dahl, Allison Poppel, Saeed Al-Azazi   +5 more
doaj   +1 more source

Study protocol for validation of the safety and efficacy of topical steroid therapy targeting nasal-associated lymphoid tissue in IgA nephropathy : a single-centre, open-label, historical controlled study

, 2022
Abstract Background IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Approximately 30–40% of patients progress to end-stage renal disease over 20 years. Mucosal immune dysregulation in nasal-associated lymphoid tissue (NALT) may be involved in the pathogenesis of IgAN.
Mingfeng Lee, Hitoshi Suzuki, Rina Kato, Maiko Nakayama, Yusuke Fukao, Toshiki Kano, Yuko Makita, Takashi Kobayashi, Daisuke Sato, Masao Kihara, Shuko Nojiri, Yusuke Suzuki   +11 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source