Results 121 to 130 of about 2,566,277 (265)

Validation of Models: Statistical Techniques and Data Availability

This paper shows which statistical techniques can be used to validate simulation models, depending on which real-life data are available. Concerning this availability three situations are distinguished (i) no data, (ii) only output data, and (iii) both ...
Kleijnen, J.P.C.
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Noninvasive Measurement of Infant Respiration During Sleep: A Validation Study. [PDF]

Sensors (Basel)
Horger MN, Lucchini M, Thakur S, Spencer RMC, Barnett N.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Myocarditis after COVID-19 mRNA vaccination in Norway: a nationwide validation study. [PDF]

Open Heart
Hagen BS, Vlaisavljevic K, Oppedal LS, Endresen J, Mohn VS, Fladseth K, Lysaker TM, Ribe MP, Möller TF, Hole TL, Dahl J, Karlstad Ø, Gulseth HL, Olsen DB, Greve-Isdahl M, Watle SV, Estensen ME, Broch K, Haugaa KH, Hasselberg NE.   +19 more
europepmc   +1 more source

Understanding the Dragons of Inaction: a validation study of the psychometric properties

In 2019, Lacroix et al. developed the Dragons of Inaction Psychological Barriers scale (DIPB), which is a 22-item measure of psychological barriers (i.e., mental roadblocks) to engage in pro-environmental behaviour (PEB).
Tess, Victoria
core  

Longitudinal variable selection by cross-validation in the case of many covariates [PDF]

Longitudinal models are commonly used for studying data collected on individuals repeatedly through time. While there are now a variety of such models available (Marginal Models, Mixed Effects Models, etc.), far fewer options appear to exist for the ...
Eva Cantoni, Chris Field, Joanna Mills Flemming, Elvezio Ronchetti   +3 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Automated H-Scoring in Muscle-Invasive Bladder Cancer IHC: An Internal Validation Study. [PDF]

Diagnostics (Basel)
Yap M, Mihai IM, Alanazi MAA, Olteanu GE, Contreras-Sanz A, Black P, Wang G.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source