Results 261 to 270 of about 4,984,553 (349)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Radiomics-Based AI Model to Assist Clinicians in Intracranial Hemorrhage Diagnosis: External Validation Study. [PDF]

JMIR Form Res
Angkurawaranon S, Jitmahawong N, Unsrisong K, Thabarsa P, Madla C, Vuthiwong W, Sudsang T, Angkurawaranon C, Traisathit P, Inkeaw P.   +9 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Digital Bioimpedance for Physical Activity Detection in Type-2 Diabetes: Quasi-Experimental Validation Study. [PDF]

JMIR Diabetes
Kimura A, Onozawa S, Ogiwara T, El Ghoch M.   +3 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Intrinsic Motivation Inventory for Heart-Healthy Lifestyle (IMI-HeartLife) in Cardiovascular Disease Prevention: A Validation Study. [PDF]

Nurs Open
Choo J, Noh S, Shin Y.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Machine learning for survival outcome in head and neck squamous cell carcinoma: a multicenter validation study. [PDF]

Sci Rep
Alabi RO, Guntinas-Lichius O, Elmusrati M, Almangush A, Tiblom Ehrsson Y, Laurell G, Mäkitie AA.   +6 more
europepmc   +1 more source

Comparative analysis and validation of posterior cruciate ligament management in mobile-bearing total knee arthroplasty: Meta-analysis and animal study

Yuan-Shi Zhang, Haoyu Li, Lei Zhai, Guizhou Zheng, Hao Xing, Shi-Xin Du, Xuedong Li   +6 more
openalex   +1 more source