Results 81 to 90 of about 257,106 (315)

Overweight deformations of affine toric varieties and local uniformization [PDF]

arXiv, 2014
We study Abhyankar valuations of excellent equicharacteristic local domains with an algebraically closed residue field. For zero dimensional valuations we prove that whenever the ring is complete and the semigroup of values taken by the valuation is finitely generated (which implies that the valuation is Abhyankar) the valuation can be uniformized in ...
arxiv  

Tax shields, financial expenses and losses carried forward

Cuadernos de Economía, 2016
This article deals with the proper procedure for calculating Tax Shields (TS). The calculation includes cases where Losses Carried Forward are allowed and there is financial Other Income (OI).
Ignacio Vélez-Pareja
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

The Relation between CSR and Innovation. Model Approach

Journal of Entrepreneurship, Management and Innovation, 2016
The paper attempts to fulfil the research gap concerning the mutual relation between company innovation and its corporate social responsibility practices, by determining the conditions in which the innovation/CSR relation appears and develops.
Dawid Szutowski, Piotr Ratajczak
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Ultra valuations [PDF]

arXiv, 2017
This paper proposes an original exchange property of valuations.This property is shown to be equivalent to a property described by Dress and Terhalle in the context of discrete optimization and matroids and shown there to characterize the valuations for which the demand oracle can be implemented by a greedy algorithm. The same exchange property is also
arxiv  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Poincare Series of Non-divisorial Valuations on Two-dimensional Function Fields [PDF]

arXiv, 2015
We use dual graphs and generating sequences of valuations to compute the Poincare series of non-divisorial valuations on function fields of dimension two. The Poincare series are shown to reflect data from the dual graphs and hence carry equivalent information.
arxiv