Results 91 to 100 of about 1,061,481 (358)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Costly Financing, Optimal Payout Policies and the Valuation of Corporate Debt [PDF]

open access: green, 2000
Viral V. Acharya   +3 more
openalex   +2 more sources

Concept of brand valuation: Does it really add value? [PDF]

open access: yesMarketing (Beograd. 1991), 2006
The focus of our paper will be to discuss the most important features that the concept of brand valuation faces, to make comparison of current methodologies of brand valuation, and to create conclusions/lessons how brand valuation challenges modern brand
Bazley Candice, Perović Nikola
doaj  

Valuation equations for stochastic volatility models [PDF]

open access: yes, 2011
We analyze the valuation partial differential equation for European contingent claims in a general framework of stochastic volatility models where the diffusion coefficients may grow faster than linearly and degenerate on the boundaries of the state ...
Bayraktar, Erhan   +2 more
core   +2 more sources

Earthing effects on mitochondrial function: ATP production and ROS generation

open access: yesFEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Of Principle and Principal: Value Plurality in the Market of Impact Investing

open access: yesValuation Studies, 2015
Impact investing-investment with the intentional expectation of social or environmental impact alongside financial return-constitutes one of a growing array of “concerned markets” where economic exchange is employed as a means to pursue financial and ...
Emily Barman
doaj   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

open access: yesFEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo   +4 more
wiley   +1 more source

Dynamic Financial Valuation of Football Players: A Machine Learning Approach Across Career Stages

open access: yesInternational Journal of Financial Studies
The financial valuation of professional football players is influenced by multiple factors that evolve throughout a player’s career. This study examines these determinants using Gradient Boosting Machine Learning models, segmented by three age categories
Danielle Khalife   +4 more
doaj   +1 more source

Correct or incorrect application of CAPM? Correct or incorrect decisions with CAPM? [PDF]

open access: yes
This paper focuses on inconsistencies arising from the use of NPV and CAPM for capital budgeting. It shows that (i) CAPM capital budgeting decision-making based on disequilibrium NPV is deductively inferred by the Capital Asset Pricing Model, (ii) the ...
Magni, Carlo Alberto
core   +1 more source

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