Results 91 to 100 of about 249,987 (395)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

What do you do when the binomial cannot value real options? The LSM model

open access: yesCogent Economics & Finance, 2014
The Least-Squares Monte Carlo model (LSM model) has emerged as the derivative valuation technique with the greatest impact in current practice. As with other options valuation models, the LSM algorithm was initially posited in the field of financial ...
S. Alonso, V. Azofra, G. De La Fuente
doaj   +1 more source

Fuzzy real options valuation for oil investments

open access: yesTechnological and Economic Development of Economy, 2009
Traditional valuation methods are less viable under uncertainty. Hence, other methods such as real options valuation models, which can minimize uncertainty, have become more important.
İrem Uçal, Cengiz Kahraman
doaj   +1 more source

Application of the American Real Flexible Switch Options Methodology A Generalized Approach [PDF]

open access: yes
The paper deals with the inclusion of flexibility in financial decision-making under risk. It describes the application of the real options methodology with the possibility of sequential multinomial decision-making. The basic intention is to describe and
Zdenìk Zmeškal
core  

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

The Valuation of Real Options in a Hybrid Environment

open access: yesOperations Research and Decisions, 2019
The aim of this paper is to present the possibilities and purposefulness of the application of fuzzy set theory to the valuation of real options. Owing to temporal fluctuations in the market, some input parameters in a model of a real option cannot ...
Bogdan Rębiasz
doaj  

Real Option Applications to Information Security [PDF]

open access: yes
Real options present advantages over the standard discounting methods. In this paper we analyze them briefly and examine their potential applications on information security.
Pythagoras PETRATOS
core  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

INCENTIVOS GOVERNAMENTAIS EM PPP: UMA ANÁLISE POR OPÇÕES REAIS [PDF]

open access: yesRAE: Revista de Administração de Empresas, 2012
On November 2005 the State Government of São Paulo, Brazil, announced the intention to bid a contract to provide passenger services for the Line 4 of the São Paulo Metropolitan Subway System.
Leonardo Lima Gomes   +3 more
doaj  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

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