Results 181 to 190 of about 247,054 (301)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Policy shaping based on the learned preferences of others accounts for risky decision-making under social observation. [PDF]

Elife
Seon H, Chung D.
europepmc   +1 more source

Option Valuation with Long-Run and Short-Run Volatility Components [PDF]

, 2008
Peter Christoffersen, Kris Jacobs, Chayawat Ornthanalai, Yintian Wang   +3 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Monte Carlo-Integrated Valuation of Call Options in Leasehold Solid Mineral Property Development in Nigeria

Journal of Applied Sciences and Environmental Management
The existing closed-form models for the valuation of call options in solid mineral land use/development; (including the Samuelson-McKean model) often feature deterministic inputs and outputs that inadequately account for the dynamics of risk and ...
J. O. Ataguba, J. C. Onyejiaka
doaj  

Estimating the impact of pill burden on health utilities in hemodialysis therapy. [PDF]

Sci Rep
Shimoda H, Taniguchi M, Yamamoto S, Igarashi A, Tokunaga S, Hanada K, Tashiro N, Murata T, Asada S.   +8 more
europepmc   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Prioritization of Users in Ecosystem Service Valuation: Implications for the Design of Differentiated Conservation Policies. [PDF]

Ecol Evol
Sánchez Toledano BI, Bravo MB, Vázquez RG, López Santiago MA.   +3 more
europepmc   +1 more source

Diversification with the Option-to-Abandon: An Integrated Valuation Model [PDF]

, 2008
Carlos Alberto de Souza
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source