Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Parametric Properties of Semi-Nonparametric Distributions, with Applications to Option Valuation [PDF]
, 2009 Ángel León +2 more
openalex +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Largely Intact But Less Reliable and Distributed Neural Representations of Subjective Value in Human Opioid Addiction. [PDF]
J NeurosciLoFaro FM +5 more
europepmc +1 more source
A parabolic variational inequality arising from the valuation of strike reset options
, 2006 Zhou Yang, Fahuai Yi, Min Dai
openalex +1 more source
Valuation of Timber Harvest Contracts as American Call Options with Modified Least-Squares Monte Carlo Algorithm [PDF]
, 2010 Stanislav Petrasek, John Perez‐Garcia
openalex +1 more source
Molecular Oncology, EarlyView.In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa +14 more
wiley +1 more source
The advantages of seeing the silver lining: how valuing emotions moderates the link between ambivalent ties and daily health. [PDF]
J Gerontol B Psychol Sci Soc SciBrown CJ +3 more
europepmc +1 more source
The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, EarlyView.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
Feedback from an avatar facilitates risk-taking by modulating the amygdala response to feedback uncertainty. [PDF]
PLoS BiolTanaka T, Haruno M.
europepmc +1 more source