Results 51 to 60 of about 250,820 (303)

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Exploring Interest Rate Dynamics on Real Option Valuation for Private Equity

The Anáhuac Journal
This study analyzes the impact of interest rates on real option valuation in private equity, a highly volatile sector. Unlike traditional models such as discounted cash flows (DCF) or internal rate of return (IRR), real options incorporate not only the ...
Luisa Alejandra Vilches Murillo, Iván Adolfo Valdovinos Hernández   +1 more
doaj   +1 more source

Real Options Application in Valuing “South Pars Gas Field” Development Project [PDF]

Pizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2014
In this paper we provide an introduction to real options in valuing investment projects. Since one of the real options applications is valuing oil and gas development projects with high uncertainty and considerable investment costs, in this research we ...
mansoor khalili araghi, akbar kamijani, zeinab kasraee   +2 more
doaj  

Application of Real Options on the Decision-Making of Mining Investment Projects Using the System Dynamics Method

IEEE Access, 2019
Estimating the valuation of mining projects has great significance for investment decision-making. Since the existing valuation methods are not appropriate for mining projects affected by various uncertainties over the long term, this paper presents a ...
Di Liu, Guoqing Li, Nailian Hu, Zhaoyang Ma   +3 more
doaj   +1 more source

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Methodological and Practical Problems of Real Option Valuations

Contemporary Economics, 2007
The article deals with the problem of application the financial options valuation theory into the real options valuation. It consists three parts. The first one presents the methodology background of the financial option valuation models. This part gives
Paweł Mielcarz
doaj  

The valuation of barrier options under a threshold rough Heston model

Journal of Management Science and Engineering, 2023
In this paper, we propose a novel model for pricing double barrier options, where the asset price is modeled as a threshold geometric Brownian motion time changed by an integrated activity rate process, which is driven by the convolution of a fractional ...
Kevin Z. Tong, Allen Liu
doaj   +1 more source

Option-based valuation of mortgage-backed securities [PDF]

Economic Annals, 2010
Pure econometric approaches to pricing mortgage-backed securities (MBSs) - principal pricing vehicles used by financial practitioners - fail to capture their true risks. This point was powerfully driven home by the global financial crisis.
Ana Manola, Branko Uroševic
openaire   +2 more sources

Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. Methods We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332.
Jacquelyn N. Crane, Wei Xue, Amira Qumseya, Thomas Scharschmidt, Kathryn R. Tringale, Oscar Lopez Nunez, Jiaqi Hu, Donald A. Barkauskas, Rajkumar Venkatramani, Sheri L. Spunt, Aaron R. Weiss, Noah C. Federman   +11 more
wiley   +1 more source