Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Entropy-Based Patent Valuation: Decoding "Costly Signals" in the Food Industry via a Robust Entropy-TOPSIS Framework. [PDF]
Entropy (Basel)Li X, Liu W, Liang X, Zhou A.
europepmc +1 more source
History of Valuation Theory -- Part I
, 2007 The theory of valuations was started in 1912 by the Hungarian mathematician Josef Kursch'ak who formulated the valuation axioms as we are used today. The main motivation was to provide a solid foundation for the theory of p-adic fields as defined
Peter Roquette
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
"A girl playing soccer?": a qualitative study of capital conversion and gendered power structures among Korean female athletes. [PDF]
BMC PsycholAhn H, Choi NY.
europepmc +1 more source
History of Valuation Theory -- Part I
, 2003 The theory of valuations was started in 1912 by the Hungarian mathematician Josef Kürschák who formulated the valuation axioms as we are used today. The main motivation was to provide a solid foundation for the theory of p-adic fields as defined by Kurt ...
Peter Roquette
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Accounting for the Opportunity Cost of Children's Time in Economic Evaluation: Challenges and Frequently Asked Questions. [PDF]
Health EconAndronis L +4 more
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Psychometric evaluation of the Values Inventory: structural validity, internal consistency, and the integration with sleep value in a U.S. adult online sample. [PDF]
Front SleepSherriff D +5 more
europepmc +1 more source