Results 131 to 140 of about 53,466 (260)
Applying stress-testing on value at risk (VaR) methodologies
, 2018 In recent years, Value at Risk (VaR) methodologies, i. e., Parametric VaR, Historical Simulation and the Monte Carlo Simulation have experienced spectacular growth within the new regulatory framework which is Basle II. Moreover, complementary analyses such a Stress-testing and Back-testing have also demonstrated their usefulness for financial risk ...
Feria Domínguez, José Manuel +1 more
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
How the Sino-U.S. Trade War Rewired Global Soybean Price Linkages: Time-Varying Spillovers and Frequency-Domain Evidence. [PDF]
FoodsZhang Q, Hu Y, Yue Y.
europepmc +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Persistently low blood eosinophils identify a high-risk phenotype in COPD. [PDF]
BMC Pulm MedZhang W +7 more
europepmc +1 more source
Value at Risk (VaR). Empirical parametric models and evaluation
, 2017 We compare the performance of two parametric methods with one non parametric for day-to-day Value-at-Risk models for 63 stocks traded in NYSE or NASDAQ for three different sample sizes and two significance levels. We find that Historical Simulation is more accurate, but also more dependent on its past VaR violations than GARCH and Variance Covariance ...
openaire +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Signed Connectedness Among Cryptocurrencies, NFTs, and Foreign Exchange Markets. [PDF]
Entropy (Basel)Yang S, Zhang X, Xu W.
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source