Results 101 to 110 of about 1,909,523 (262)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Content validity of self-reports of excess skin after bariatric surgery: protocol for a Dutch cross-sectional study

BMJ Open
Introduction Body contouring surgery (BCS) can be applied to reduce the physical and mental burden of excess skin after massive weight loss. Self-reported outcomes of patients are used to assess this burden and to evaluate the effectiveness of BCS.
Rinie Geenen, Lea M Dijksman, Aebele B Mink van der Molen, Lilian Laura van Hogezand, Wouter J M Derksen   +4 more
doaj   +1 more source

Evaluating clinician experience in value-based health care: the development and validation of the Clinician Experience Measure (CEM). [PDF]

BMC Health Serv Res, 2022
Harrison R, Manias E, Ellis L, Mimmo L, Walpola R, Roxas-Harris B, Dobbins T, Mitchell R, Cowie S, Maberly G, Chan C, Hay L.   +11 more
europepmc   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Older Adults’ Access to Pharmacological Treatment, a Human Right to Health: Scoping Review (2020–2025)

Pharmacy
Background: Limitations in timely and equitable access to essential medicines among older adults not only constitute a clinical barrier to the effective management of chronic conditions, but also represent a violation of the fundamental right to life ...
Doris Cardona, Valeria Santacruz-Restrepo, Juliana Madrigal-Cadavid, Alejandra Rendón-Montoya, Angela Segura-Cardona, Jorge Iván Estrada-Acevedo, Marcela Agudelo-Botero   +6 more
doaj   +1 more source

[Flu vaccination and value-based health care: operational solutions to safeguard public health]. [PDF]

J Prev Med Hyg, 2022
Calabrò GE, Icardi G, Bonanni P, Gabutti G, Vitale F, Rizzo C, Cicchetti A, Staiano A, Ansaldi F, Orsi A, DE Waure C, Panatto D, Amicizia D, Bert F, Villani A, Ieraci R, Conversano M, Russo C, Rumi F, Scotti S, Maio T, Russo R, Vaccaro CM, Siliquini R, Ricciardi W.   +24 more
europepmc   +1 more source

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Redesigning value-based hospital structures: a qualitative study on value-based health care in the Netherlands. [PDF]

BMC Health Serv Res, 2022
Steinmann G, Daniels K, Mieris F, Delnoij D, van de Bovenkamp H, van der Nat P.   +5 more
europepmc   +1 more source

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Oral health literacy from a person-centered focus in the United States: a narrative review

BMC Oral Health
Background The concept of oral health literacy (OHL) is well recognized in the literature as a contributing factor to poor oral and systemic health outcomes.
Kelly L. Schroeder, Caroline McLeod, Stephanie Clester, Hanna J. Cheung, Lisa J. Heaton, Eric P. Tranby   +5 more
doaj   +1 more source