Results 91 to 100 of about 61,101 (256)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Eco-Friendly Product Purchasing Behavior Based on the Theory of Consumption Value

Indonesian Interdisciplinary Journal of Sharia Economics
This study investigates eco-friendly product purchasing behavior among millennial consumers based on the Theory of Consumption Value. Using a quantitative approach and multiple regression analysis, the research examines the effects of functional ...
Bernadetta Diansepti Maharani, Lusia Tria Hatmanti Hutami, Dika Prawita, Budi Setiawan, Friska Putri Wati   +4 more
doaj  

A study on the mechanism of live streamer's behavior characteristics affecting consumers' impulsive buying: The role of perceived value and social identity

Acta Psychologica
With the development of live-streaming e-commerce, consumer needs have expanded beyond pure consumption to include emotional fulfillment, group belonging, and value recognition.
Li Yu, Wenchen Tang, Weiheng Gao
doaj   +1 more source

Evaluating the robustness of the CMS Hospital Value-Based Purchasing measurement system. [PDF]

Health Serv Res, 2021
Revere L, Langland-Orban B, Large J, Yang Y.   +3 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Factors Influencing Consumer Purchasing Decisions for Fruit Drinks:The Role of Nutritional Claims in Gampaha District, Sri Lanka

Икономика и управление на селското стопанство
Nutritional claims refer to statements or labels on food and beverage products that highlight their nutritional content, health benefits, or ingredient-related attributes.
S. S. K. De Silva, S. H. P. Malkanthi, K. D. M. L. Piyasena, P. Shivashankar   +3 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Recommendation for a Pilot MCDA Tool to Support the Value-Based Purchasing of Generic Medicines in the UAE. [PDF]

Front Pharmacol, 2021
Farghaly MN, Al Dallal SAM, Fasseeh AN, Monsef NA, Suliman EAMA, Tahoun MA, Abaza S, Kaló Z.   +7 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source