Results 101 to 110 of about 760,668 (282)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

COST BENEFIT ANALYSIS ANTARA PEMBELIAN ALAT CT-SCAN DENGAN ALAT LASER DIODA PHOTOCOAGULATOR DI RSD BALUNG JEMBER

Jurnal Ilmu Kesehatan Masyarakat, 2015
Cost benefit analysis is an economic analysis that is used to evaluate economic resources usage so that the scarce economic resources can be used efficiently.
Nuryadi Nuryadi, Yennike Tri Herawati, Rafida Triwardhani   +2 more
doaj  

Hospital value-based purchasing: How acute care advanced practice nurses demonstrate value. [PDF]

J Am Assoc Nurse Pract, 2021
Constable M, Mulkey M, Aucoin J.
europepmc   +1 more source

The Total Value of the $1 Federal Reserve Note: Factoring in Physicality and the Consumer [PDF]

Consumers are using cash less often. This is especially the case in high-value transactions. However, the $1 Federal Reserve Note continues to hold its ground in the realm of micropayments, transactions having a value of less than $5.
Noll, Franklin
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evaluating the robustness of the CMS Hospital Value-Based Purchasing measurement system. [PDF]

Health Serv Res, 2021
Revere L, Langland-Orban B, Large J, Yang Y.   +3 more
europepmc   +1 more source

Exchange-Rate Risk Mitigation with Price-Level-Adjusting Mortgages: The Case of the Mexican UDI [PDF]

In 1995, Mexico introduced a credit system based on a price-level-adjusting unit of account called the Unidad de Inversion (UDI, pronounced “oo-dee”), which is Spanish for “unit of investment.” The Bank of Mexico maintains an UDI Index, which sets the ...
Harold Hunt, John T. Harvey, Joseph B. Lipscomb   +2 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Creating A Multi-Criteria Decision Analysis Tool to Enhance Value-Based Purchasing of Generic and Biosimilar Medications in Saudi Arabia: A Pilot Study

ClinicoEconomics and Outcomes Research
Yazed Alruthia,1,2 Horiyah Alhajri,1 Omar A Almohammed,1 Bander Balkhi,1 Mai F Alsaqa’aby,2 Mohammed A Almuqbil,3– 5 Hana A Al-Abdulkarim,6 Abdulaali R Almutairi7 1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ...
Alruthia Y, Alhajri H, Almohammed OA, Balkhi B, Alsaqa’aby MF, Almuqbil MA, Al-Abdulkarim HA, Almutairi AR   +7 more
doaj  

Applying total cost of ownership for strategic procurement : three industrial case studies. [PDF]

In this paper we elaborate on a Total Cost of Ownership supplier selection methodology that we have constructed using three real life case studies which are presented in this article.
Degraeve, Zeger, Labro, Eva, Roodhooft, Filip   +2 more
core