Results 161 to 170 of about 47,086,790 (308)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Time-varying conditional Johnson SU density in value-at-risk (VaR) methodology [PDF]

Stylized facts on financial time series data are the volatility of returns that follow non-normal conditions such as leverage effects and heavier tails leading returns to have heavier magnitudes of extreme losses.
Cayton, Peter Julian A., Mapa, Dennis S.
core  

Sequential ultrasound in arthralgia patients at risk for inflammatory arthritis: is it of added value in risk stratification? [PDF]

Scand J Rheumatol, 2023
Rogier C, Kortekaas MC, van der Helm-van Mil A, de Jong P, van Mulligen E.   +4 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A value at risk analysis of cedit default swaps [PDF]

We investigate the risk of holding credit default swaps(CDS) in the trading book and compare the Value at Risk (VaR) of a CDS position to the VaR for investing in the respective firm’s equity using a sample of CDS – stock price pairs for 86 actively ...
Scheicher, Martin, Raunig, Burkhard
core  

Limited change in adolescent value-based risk choices following acute sleep restriction and caffeine. [PDF]

Front Psychol
Lane LT, Capdevila NC, Loock AS, Mattern E, Cajochen C, Reichert CF.   +5 more
europepmc   +1 more source

Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass. [PDF]

Mol Clin Oncol, 2022
Huwidi A, Abobrege A, Assidi M, Buhmeida A, Ermiah E.   +4 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Value at risk models in finance [PDF]

The main objective of this paper is to survey and evaluate the performance of the most popular univariate VaR methodologies, paying particular attention to their underlying assumptions and to their logical flaws.
Manganelli, Simone, Engle, Robert F.
core  

Pan-Immune-Inflammatory value and risk of latent tuberculosis infection. [PDF]

Sci Rep
Ye X, Kang X, Zhang H, Wang W.
europepmc   +1 more source