Results 141 to 150 of about 53,651 (258)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of Self-Assembling Peptide on White Spot Lesions in Orthodontic Patients: A Systematic Review and Meta-Analysis. [PDF]

Clin Exp Dent Res
Shakir S, Umer F, Khalid Q, Shahzad K, Hussain U, Mohammad S, Omair H, Campobasso A, Naseem W, Khan J.   +9 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Functional, Nutritional and Biological Properties of Ice Cream Produced by Yeast Inoculation. [PDF]

Food Sci Nutr
Denizkara AJ, Kilinç M, Akarca G.
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

An alternative strategy for balancing profit maximization and risk reduction. [PDF]

PLoS One
El Khatib Y, Mukhamedova F.
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Integrating spatial lymph node patterns and multimodal clinicopathological features to predict post-neoadjuvant recurrence in gastric adenocarcinoma: a machine learning nomogram. [PDF]

BMC Cancer
Fazhi Z, Shangzhi H, Zhi D, Yang L, Shuomeng X, Yehan Z.   +5 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Validation of screening criteria for interstitial lung disease in rheumatoid arthritis in routine clinical practice: the VAR-EPIDSER study. [PDF]

RMD Open
Mena-Vázquez N, Domínguez-Álvaro M, Bonilla Hernán MG, Atienza-Mateo B, Fernández Velilla Peña M, Pinilla Fernández I, Ortiz AM, Park HS, Gomez NP, Plasencia-Rodríguez C, Aguilar Hurtado MC, Holgado Pérez S, Serrano-Combarro A, Vegas-Revenga N, Bernal Vidal JA, Lacasa-Molina J, Burger S, Campos Fernández C, Fiter Aresté J, Meraz Ostiz JA, Muñoz Gómez MDM, Alvaredo D, Castañeda S, VAR-EPIDSER Project Collaborating Group.   +23 more
europepmc   +1 more source